1421373-08-1

Basic information

• Product Name: N-(4-bromo-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-Pyrimidinamine
• Synonyms: N-(4-bromo-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-Pyrimidinamine
• CAS NO: 1421373-08-1
• Molecular Weight: 454.283
• Mol File: 1421373-08-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-bromo-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-Pyrimidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-Pyrimidinamine(1421373-08-1)
• EPA Substance Registry System: N-(4-bromo-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-Pyrimidinamine(1421373-08-1)

Safety Data

• Hazardous Substances Data: 1421373-08-1(Hazardous Substances Data)

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 603-76-9 1-methylindole 
• 120-72-9 indole 
• 59557-91-4 4-bromo-2-methoxyaniline 
• 945016-63-7 3-(2-chloro-pyrimidin-4-yl)-1H-indole 
• 1032452-86-0 2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine 
• 1421371-97-2 4-bromo-2-methoxy-5-nitrobenzenamine 

Downstream Products

• 1421373-86-5 C₂₉H₃₀N₆O₂ 
• 1421373-06-9 4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine 
• 1421373-07-0 4-bromo-6-methoxy-N-[4-(1-methylindol-3-yl)pyrimidin-2-yl]-benzene-1,3-diamine 

Relevant articles and documents

EGFR tyrosine kinase of selective inhibitors of clinically significant mutant

Kinase can be prevented by the compound and the salt, especially epidermal growth factor receptor (EGFR,erbB-2,erbB-4) and kinase clinica important gatekeeper 'mutant'; and abnormal cell profilerative diseases such as cancers can be treated or improved.