142-91-6 Usage
Description
Isopropyl palmitate is an aliphatic ester that is derived from the combination of palmitic acid (found in coconut or palm oil) and isopropyl alcohol. It is a clear, colorless to pale yellow-colored, practically odorless viscous liquid that solidifies at less than 16°C. Isopropyl palmitate is metabolized by enzymes and is known for its moisturizing, emollient, and solvent properties. It is also used as a binder in various applications.
Uses
Used in Pharmaceutical Industry:
Isopropyl palmitate is used as a pharmaceutic aid for its oleaginous properties, acting as a vehicle in the formulation of medications.
Used in Cosmetics and Personal Care Industry:
Isopropyl palmitate is used as an emollient and moisturizer in cosmetics and personal care products, providing a smooth and soft texture to the skin.
Used in Food Industry:
Isopropyl palmitate is used as a flavoring ingredient in the food industry, contributing to the taste and aroma of various products.
Used in Topical Application Formulation:
Isopropyl palmitate is used to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application, enhancing the delivery and effectiveness of the medication.
Used in Microemulsion System Characterization:
Isopropyl palmitate is utilized in the characterization of microemulsion systems, which involve isopropyl palmitate, water, and other components like Brij 97 and 1-butanol, to study their properties and potential applications in various industries.
Production Methods
Isopropyl palmitate is prepared by the reaction of palmitic acid with
propan-2-ol in the presence of an acid catalyst. A high-purity
material is also commercially available, which is produced by
enzymatic esterification at low temperatures.
Pharmaceutical Applications
Isopropyl palmitate is a nongreasy emollient with good spreading
characteristics, used in topical pharmaceutical formulations and
cosmetics such as: bath oils; creams; lotions; make-up; hair care
products; deodorants; lip products; suntan preparations; and
pressed powders.
Isopropyl palmitate is an established penetration enhancer for
transdermal systems. It has also been used in controlled-release
percutaneous films.
Table I: Uses of isopropyl palmitate
Safety
Isopropyl palmitate is widely used in cosmetics and topical
pharmaceutical formulations, and is generally regarded as a
relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg
storage
Isopropyl palmitate is resistant to oxidation and hydrolysis, and
does not become rancid. It should be stored in a well-closed
container, above 16°C, and protected from light.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical and
transdermal preparations). Used in nonparenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 142-91-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 142-91:
(5*1)+(4*4)+(3*2)+(2*9)+(1*1)=46
46 % 10 = 6
So 142-91-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H38O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19(20)21-18(2)3/h18H,4-17H2,1-3H3
142-91-6Relevant articles and documents
Mammalian exocrine secretions. XIV: Constituents of preorbital secretion of steenbok, Raphicerus campestris
Burger,Greyling,Spies
, p. 2099 - 2108 (1999)
In a study aimed primarily at qualitative comparison of the organic constituents of the preorbital secretion of the steenbok, Raphicerus campestris, with those previously found in the preorbital secretion of the grysbok, R. melanotis, 109 compounds were identified in the secretion of the steenbok. Although the secretions from the two antelope are similar in that they are mostly long-chain, unbranched, saturated and unsaturated alcohols and various derivatives of these alcohols, only 22 of the identified compounds are present in both secretions. This is a small percentage of the more than 260 compounds present in the secretion of the steenbok, which is much more complex than that of the grysbok.
Method for synthesis of long-chain fatty acid ester derivative
-
Paragraph 0029-0030, (2020/01/12)
The invention relates to a method for synthesis of a long-chain fatty acid ester derivative. Specifically, a hydrochloride of glycine methyl ester or glycine ethyl ester is used as a catalyst to catalyze the esterification reaction of long-chain fatty acid. The method includes: subjecting alcohol and long-chain fatty acid to esterification reaction under the action of the catalyst at certain temperature condition, then conducting extraction and precipitation with ethyl acetate, performing flushing with a sodium chloride aqueous solution for purification. A hydrochloride of glycine methyl esteror glycine ethyl ester is adopted as the catalyst, which belongs to a green catalyst, is the development trend of modern chemistry, has the characteristics of no corrosion to the reaction kettle, lowprice, no toxicity and the like, and is suitable for use as a catalyst to produce palmitate and laurate perfume raw materials.
USE OF ENDOCANNABINOID-LIKE COMPOUNDS FOR TREATING CNS DEGENERATIVE DISORDERS
-
Paragraph 0054-0056, (2017/09/12)
no abstract published
Zirconium-containing metal organic frameworks as solid acid catalysts for the esterification of free fatty acids: Synthesis of biodiesel and other compounds of interest
Cirujano,Corma,Llabrés I Xamena
, p. 213 - 220 (2015/02/19)
Zr-containing metal organic frameworks (MOFs) formed by terephthalate (UiO-66) and 2-aminoterephthalate ligands (UiO-66-NH2) are active and stable catalysts for the acid catalyzed esterification of various saturated and unsaturated fatty acids with MeOH and EtOH, with activities comparable (in some cases superior) to other solid acid catalysts previously reported in literature. Besides the formation of the corresponding fatty acid alkyl esters as biodiesel compounds (FAMEs and FAEEs), esterification of biomass-derived fatty acids with other alcohols catalyzed by the Zr-MOFs allows preparing other compounds of interest, such as oleyl oleate or isopropyl palmitate, with good yields under mild conditions.