141829-04-1

Basic information

• Product Name: Propanedioic acid, (2-carboxy-5-fluorophenyl)-, 1,3-dimethyl ester
• CAS NO: 141829-04-1
• Molecular Formula: C12H11FO6
• Molecular Weight: 270.214
• Mol File: 141829-04-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (2-carboxy-5-fluorophenyl)-, 1,3-dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (2-carboxy-5-fluorophenyl)-, 1,3-dimethyl ester(141829-04-1)
• EPA Substance Registry System: Propanedioic acid, (2-carboxy-5-fluorophenyl)-, 1,3-dimethyl ester(141829-04-1)

Safety Data

• Hazardous Substances Data: 141829-04-1(Hazardous Substances Data)

Upstream product

• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 1609576-10-4 N-(4-fluorobenzyl)-6-fluoro-2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1609575-96-3 N-(4-fluorobenzyl)-2-(benzyloxy)-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1609575-86-1 methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate 
• 500779-09-9 2-(carboxymethyl)-4-fluorobenzoic acid 
• 1026328-27-7 [2-(4-Bromo-2-fluoro-benzyl)-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetic acid tert-butyl ester 
• 133891-93-7 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid 
• 133915-51-2 2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolinecarboxylic acid methyl ester 
• 142371-25-3 2-(2-Chlorocarbonyl-5-fluoro-phenyl)-malonic acid dimethyl ester 

Relevant articles and documents

Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2 H,4 H)-diones as human immunodeficiency virus type 1 integrase inhibitors

We report herein further insight into the biological activities displayed by a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs). Substitution of the N-hydroxyimide two-metal binding pharmacophore at position 4 by carboxamido side chains was previously shown by us to be fruitful for this scaffold, since strong human immunodeficiency virus type 1 integrase (HIV-1 IN) inhibitors in the low nanomolar range associated with low micromolar anti-HIV activities were obtained. We investigated the influence of substitution at position 7 on biological activity. Introduction of electron-withdrawing functional groups such as the nitro moiety at position 7 led to a noticeable improvement of antiviral activity, down to low nanomolar anti-HIV potencies, with advantageous therapeutic indexes going close to those of the clinically used raltegravir and retained potencies against a panel of IN mutants.

Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones

We have developed a number of efficient protocols for the facile synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones. This synthetic methodology allowed concise and efficient exploration of the SAR in all areas of the molecule. A number of these methods pro

Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors

This invention relates to alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro[isoquinoline-4(1H),3'-pyrrolidone]-1,2',3,5'(2H)-tetrones represented by formula (I): STR1 wherein: R1, R2 and R3 are independently