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1415356-21-6

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1415356-21-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1415356-21-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,5,3,5 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1415356-21:
(9*1)+(8*4)+(7*1)+(6*5)+(5*3)+(4*5)+(3*6)+(2*2)+(1*1)=136
136 % 10 = 6
So 1415356-21-6 is a valid CAS Registry Number.

1415356-21-6Downstream Products

1415356-21-6Relevant articles and documents

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

Urbano, Mariangela,Guerrero, Miguel,Zhao, Jian,Velaparthi, Subash,Roberts, Edward,Adrian Saldanha, S.,Chase, Peter,Hodder, Peter,Wang, Zhiwei,Civelli, Olivier,Schaeffer, Marie-Therese,Brown, Steven,Rosen, Hugh

, p. 7135 - 7141,7 (2012/12/12)

Novel small molecule antagonists of NPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl) pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, synthesis and structure-activity relationships study of the HTS-derived hit led to the identification of 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule with submicromolar antagonist activity at the target receptor and high selectivity against a panel of therapeutically relevant off-target proteins. This lead molecule may provide a pharmacological tool to clarify the molecular basis of the in vivo physiological function and therapeutic utility of NPBWR1 in diverse disease areas including inflammatory pain and eating disorders.

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