141222-28-8

Basic information

• Product Name: 2-Propenoic acid, 3-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-, (2E)-
• CAS NO: 141222-28-8
• Molecular Formula: C15H22O3Si
• Molecular Weight: 278.423
• Mol File: 141222-28-8.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-, (2E)-(141222-28-8)
• EPA Substance Registry System: 2-Propenoic acid, 3-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-, (2E)-(141222-28-8)

Safety Data

• Hazardous Substances Data: 141222-28-8(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 7400-08-0 p-Coumaric Acid 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 381226-39-7 C₂₁H₃₆O₃Si₂ 

Downstream Products

• 114916-05-1 N,N′-di-p-coumaroylspermidine 
• 1428579-77-4 C₂₄H₂₈O₆S₂ 
• 1428579-78-5 C₂₂H₂₂I₂O₆ 
• 1428579-79-6 C₂₆H₂₈O₆ 
• 1428579-80-9 C₃₀H₃₆O₆ 
• 1428579-81-0 C₃₈H₄₈O₆ 
• 1428579-82-1 C₃₈H₄₈O₆ 
• 1428579-86-5 (1R,2R,3S,4S)-2,4-bis(4-((tert-butyldimethylsilyl)oxy)phenyl)cyclobutane-1,3-dicarboxylic acid 
• 1428580-01-1 C₄₀H₆₄O₈Si₂ 
• 1428580-09-9 C₃₆H₄₈F₈O₆Si₂ 
• 1428580-10-2 C₃₆H₄₄F₁₂O₆Si₂ 
• 1428580-11-3 C₃₆H₅₆O₆S₂Si₂ 
• 1428580-12-4 C₃₄H₅₀I₂O₆Si₂ 
• 1428580-13-5 C₃₈H₅₆O₆Si₂ 

Relevant articles and documents

The biosynthesis of lunarine in seeds of Lunaria annua

Using an optimized precursor feeding system, the biosynthesis of the alkaloid lunarine in Lunaria annua seeds was investigated. The synthesis of radioactively labelled precursors for the application experiments is described. Lunarine was shown to be synthesized by stereo-selective phenol- oxidative coupling of N1,N10-bis(p-coumaroyl)spermidine. p-Coumaric acid for the biosynthesis of this dimer is formed from L-phenylalanine via trans- cinnamic acid. The polyamine moiety of lunarine, spermidine, and its immediate precursor putrescine are preferentially synthesized from arginine. Enzyme studies with microsomes of Lunaria annua seeds indicated that a cytochrome P-450 enzyme might be responsible for the phenol-oxidative coupling of N1,N10-bis (p-coumaroyl)spermidine yielding the hexahydrodibenzofuran ring of lunarine.

TRPV3 inhibitor and preparation method thereof

The invention discloses a TRPV3 inhibitor. The TRPV3 inhibitor is formed by sequentially connecting an R1 group, an R group and an R2 group, and the molecular structural general formula of the TRPV3 inhibitor is shown as a formula 1, wherein the structural formula of the R1 group is represented by a formula 2, R3 is selected from any one of -H, -OAc, -OH, a halogen group, -F3CO or a group containing a benzenesulfonyloxy group, and R4 is selected from any one of -H, -OAc or -OH; R1 and R2 are selected from alkyl or formula 3, R5 is selected from C or N, R6 is selected from any one of hydrogen, alkyl, halogen group or trifluoromethyl, R7 is selected from any one of hydrogen, halogen group, cyano group, nitro group or trifluoromethoxy group, and R8 is selected from hydrogen or halogen group. The invention also discloses a preparation method and application of the TRPV3 inhibitor. The TRPV3 inhibitor disclosed by the invention can specifically inhibit a TRPV3 ion channel and has huge scientific research and clinical values.

Expedient Synthesis of Alphitolic Acid and Its Naturally Occurring 2- O-Ester Derivatives

The expedient synthesis of alphitolic acid (1) as well as its natural C-3-epimer and 2-O-ester derivatives was accomplished in a few steps from the readily commercially available betulin (9). A Rubottom oxidation delivered an α-hydroxy group in a stereo- and chemoselective manner. The diastereoselective reduction of the α-hydroxy ketone was key to accessing the 1,2-diol moiety of this class of natural products. Our concise and stereoselective synthetic protocol allowed the gram-scale synthesis of these natural products, which will facilitate future biological evaluations.

Semi-natural-source tyrosinase inhibitor and preparation method and application thereof

The invention discloses a semi-natural-source tyrosinase inhibitor and a preparation method and application thereof. P-hydroxy cinnamic acid which is a natural product is used as a raw material to synthesize (E)-3-(4-hydroxy phenyl) acrylic acid-2-acetyl-