14110-64-6 Usage
Description
Cytochalasin A is a potent mycotoxin derived from certain fungi, which significantly impacts cytoskeletal proteins, leading to pronounced morphogenic activity in both animals and plants. It is an oxidized analog of cytochalasin B and is known for its ability to inhibit actin polymerization, which interferes with various cellular processes such as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A also exhibits unique properties, such as inhibiting HIV-1 protease and binding to glucose transporters, affecting monosaccharide transport across the plasma membrane.
Uses
Used in Pharmaceutical Applications:
Cytochalasin A is used as a research tool for studying the role of actin in cellular processes due to its potent inhibition of actin filament function, leading to cell death by apoptosis. This property makes it valuable in understanding the mechanisms behind cell growth, movement, and other related processes.
Used in Antiviral Applications:
Cytochalasin A is used as an inhibitor of HIV-1 protease, with an IC50 of 3 μM. This application highlights its potential in the development of antiretroviral therapies and understanding the interactions between the toxin and the viral protease.
Used in Cell Biology Research:
Cytochalasin A is used as a reagent in cell biology research to investigate the effects of actin polymerization inhibition on cellular actions and to study the role of glucose transport in cellular processes. It helps researchers understand the diverse selectivity of cytochalasins and their impact on cellular functions.
Used in Fungal Metabolite Studies:
As a white powder, cytochalasin A is used in the study of fungal metabolites, their chemical properties, and their potential applications in various fields, including medicine and biotechnology.
Used in Saccharomyces Strain Research:
Cytochalasin A is used as an inhibitor of monosaccharide transport in a Saccharomyces strain, preventing growth and sugar uptake. This application aids in understanding the role of glucose transport in yeast metabolism and the potential for targeted interventions in yeast-related processes.
Biochem/physiol Actions
Cytochalasin A reacts with sulfhydryls, and inhibits growth and glucose transport in Saccharomyces. Cytochalasin A is an oxidizing analog of cytochalsin B.
Check Digit Verification of cas no
The CAS Registry Mumber 14110-64-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,1 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14110-64:
(7*1)+(6*4)+(5*1)+(4*1)+(3*0)+(2*6)+(1*4)=56
56 % 10 = 6
So 14110-64-6 is a valid CAS Registry Number.
InChI:InChI=1/C29H35NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,23-24,26-27,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15u/t18-,19-,23-,24-,26+,27+,29-/m0/s1
