140947-23-5

Basic information

• Product Name: 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester
• Synonyms: diethyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylate
• CAS NO: 140947-23-5
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• Mol File: 140947-23-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester(140947-23-5)
• EPA Substance Registry System: 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester(140947-23-5)

Safety Data

• Hazardous Substances Data: 140947-23-5(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester is a chemical compound that consists of a pyrrolizine ring with two carboxylic acid groups. It also has a benzoyl group attached to the 5th position of the ring and two ethyl ester groups. 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester is often used in organic synthesis and pharmaceutical research as a building block for creating more complex molecules. It may have potential applications in drug development due to its structural and chemical properties. However, it is important to handle this compound with care as it may have potential hazards if not used properly.

Upstream product

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Downstream Products

• 74103-06-3 Ketorolac 

Relevant articles and documents

Preparation method of ketorolac

The present invention relates to the field of medicine, specifically a method of preparation of ketorolac, in the process of preparing ketorolac using alkaline hydrolyzed intermediate A5, borohydride is added, the sample of ketorolac obtained is examined in accordance with the Chinese Pharmacopoeia solution color inspection method, significantly lighter than the sample color obtained by the prior art, the preparation method of ketorolac of the present invention, compared with the prior art in the process of salting with tromethamine, compared with the method of using reducing sulfide in the process of salting with tromethamine, can avoid the risk of incandescent residue unqualified, providing convenience for the staff.

Ketorolac tromethamine intermediate compound VI

The invention belongs to the technical field of drug synthesis, and particularly relates to a ketorolac tromethamine intermediate compound VI. The synthesis method of the ketorolac tromethamine intermediate compound VI comprises the following steps: adding a compound V into a reaction solvent, slowly adding alkali in batches at controlled temperature, reacting at constant temperature after the addition is finished, cooling after the reaction is finished, dropwise adding a compound IV into the reaction system, performing temperature-controlled reaction after dropwise adding is completed, and adjusting pH after the reaction is completed; evaporating under reduced pressure to remove the solvent, adding an extraction solvent into residues for extraction, collecting an organic layer, filtering and drying to obtain the compound VI. The invention provides a novel method for synthesizing a ketorolac tromethamine intermediate compound by using the intermediate, and the method is simple and convenient to operate; starting raw materials are easy to obtain, highly toxic and highly corrosive substances are not used in the reaction, the reaction steps are few, the operation is simple, and the method is suitable for industrial production; the reaction speed is high, impurities are few, the reaction yield and purity are improved, and the cost is reduced.

Improved preparation method of ketorolac intermediate

The invention discloses an improved preparation method of a ketorolac intermediate. The intermediate is (5-Benzoyl-1H-pyrrol-2-yl)methanetricarboxylic acid triethyl ester (M-1). The method comprises the following steps: subjecting 2-benzoylpyrrole, methane tricarboxylic acid triethyl ester, manganese acetate dihydrate (trivalent), sodium acetate and acetic anhydride to reacting in an organic solvent; adding an aqueous sodium hydrogen sulfite solution for extraction and liquid separation; and conducting vacuum concentration on an organic phase and pulping the an organic phase with an alcohol solvent. According to the method, post-treatment problems caused by the existence of a large amount of manganese ion compounds and a large amount of solvent acetic acid are effectively solved; meanwhile, the problems of high energy consumption, long period, high cost and the like caused by later concentration are reduced; and the obtained intermediate has the advantages of high purity, high yield and the like and is suitable for industrial production.