14058-83-4

Basic information

• Product Name: ethyl 1-(4-chlorophenyl)-5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate
• Synonyms: ethyl 1-(4-chlorophenyl)-5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate
• CAS NO: 14058-83-4
• Molecular Weight: 280.711
• Mol File: 14058-83-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 1-(4-chlorophenyl)-5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(4-chlorophenyl)-5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate(14058-83-4)
• EPA Substance Registry System: ethyl 1-(4-chlorophenyl)-5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate(14058-83-4)

Safety Data

• Hazardous Substances Data: 14058-83-4(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 140-38-5 N-(4-chlorophenyl)urea 

Relevant articles and documents

Design and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives bearing an imidazolone moiety as c-Met kinase inhibitors

A series of 4-(2-fluorophenoxy)quinoline derivatives containing an imidazolone moiety were designed, synthesized and evaluated for their in vitro biological activities against c-Met kinase and four cancer cell lines (A549, H460, HT-29 and MKN-45). Most compounds showed moderate to excellent activities in enzyme and cellular assays. The most promising analog, 58 (c-Met IC50 = 1.42 nM), displayed 2.1-, 8.6-fold increase against H460, and MKN-45 cell lines, respectively, compared with foretinib. An analysis of structure-activity relationships revealed that an ortho substituted phenyl ring as well as an N-unsubstituted imidazolone linker is favorable for antitumor activity.