14047-29-1Relevant articles and documents
Preparation, properties, and synthetic potentials of novel boronates in a fluorous version (fluorous boronates)
Chen, Dajun,Qing, Feng-Ling,Huang, Yangen
, p. 1003 - 1005 (2002)
(equation presented) 4a-j R = aryl, alkenyl, alkyl A series of boronic acids were attached to a fluorous tag by esterification. Functional transformations of these boronates together with the fluorous Suzuki coupling reaction illustrated their usefulness in fluorous-phase techniques.
Remote-Controlled Release of Singlet Oxygen by the Plasmonic Heating of Endoperoxide-Modified Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy
Kolemen, Safacan,Ozdemir, Tugba,Lee, Dayoung,Kim, Gyoung Mi,Karatas, Tugce,Yoon, Juyoung,Akkaya, Engin U.
, p. 3606 - 3610 (2016)
The photodynamic therapy of cancer is contingent upon the sustained generation of singlet oxygen in the tumor region. However, tumors of the most metastatic cancer types develop a region of severe hypoxia, which puts them beyond the reach of most therapeutic protocols. More troublesome, photodynamic action generates acute hypoxia as the process itself diminishes cellular oxygen reserves, which makes it a self-limiting method. Herein, we describe a new concept that could eventually lead to a change in the 100 year old paradigm of photodynamic therapy and potentially offer solutions to some of the lingering problems. When gold nanorods with tethered endoperoxides are irradiated at 808 nm, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. We demonstrate that the amount of singlet oxygen produced in this way is sufficient for triggering apoptosis in cell cultures. EPT sees the light: When gold nanorods with tethered endoperoxides are irradiated with near-infrared light, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. The amount of singlet oxygen generated by these nanocomposites is sufficient for triggering apoptosis in cell cultures.
-
Bettman,Branch,Yabroff
, p. 1865,1867 (1934)
-
Bedford-type palladacycle-catalyzed miyaura borylation of aryl halides with tetrahydroxydiboron in water
Zernickel, Anna,Du, Weiyuan,Ghorpade, Seema A.,Sawant, Dinesh N.,Makki, Arwa A.,Sekar, Nagaiyan,Eppinger, J?rg
, p. 1842 - 1851 (2018/02/23)
A mild aqueous protocol for palladium catalyzed Miyaura borylation of aryl iodides, aryl bromides and aryl chlorides with tetrahydroxydiboron (BBA) as a borylating agent is developed. The developed methodology requires low catalyst loading of Bedford-type palladacycle catalyst (0.05 mol %) and works best under mild reaction conditions at 40 °C in short time of 6 h in water. In addition, our studies show that for Miyaura borylation using BBA in aqueous condition, maintaining a neutral reaction pH is very important for reproducibility and higher yields of corresponding borylated products. Moreover, our protocol is applicable for a broad range of aryl halides, corresponding borylated products are obtained in excellent yields up to 93% with 29 examples demonstrating its broad utility and functional group tolerance.
A process for preparing carboxyl boric acid
-
Paragraph 0022; 0023, (2017/08/25)
The invention discloses a method for preparing carboxyl phenylboronic acid. The method comprises the following steps of starting from halogenated phenylboronic acid, heating, refluxing and dehydrating in a solvent to form a tripolymer; then forming a grignard reagent of corresponding tripolymer from tripolymer and magnesium metal or isopropyl magnesium chloride; then introducing a carbon dioxide gas at low temperature or adding dry ice for reaction; after the reaction is finished, adding hydrochloric acid, regulating till pH is equal to 2-3, and hydrolyzing; and precipitating carboxyl phenylboronic acid, filtering, and drying to obtain a pure product. The method disclosed by the invention can achieve good yield on ortho-position, meta-position and para-position carboxyl phenylboronic acid, is simple in used reagent and easy and convenient to operate and prevents the generation of a large quantity of solid wastes.