13987-61-6

Basic information

• Product Name: TERT-BUTYLAZOMETHINE
• Synonyms: 1,1-dimethyl-n-methylene-ethylamin;2-methyl-n-methylene-2-propanamin;2-methyl-n-methylene-2-propanamine;n-methylene-t-butylamine;tert-butylformaldimine;TERT-BUTYLAZOMETHINE;N-methylene-tert-butylamine;2-Methyl-2-(methyleneamino)propane
• CAS NO: 13987-61-6
• Molecular Formula: C₅H₁₁N
• Molecular Weight: 85.15
• EINECS: 237-781-4
• Mol File: 13987-61-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 87℃
• Flash Point: -3℃
• Appearance: /
• Density: 0.71
• Vapor Pressure: 72.7mmHg at 25°C
• Refractive Index: 1.393
• PKA: 7.20±0.50(Predicted)
• CAS DataBase Reference: TERT-BUTYLAZOMETHINE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYLAZOMETHINE(13987-61-6)
• EPA Substance Registry System: TERT-BUTYLAZOMETHINE(13987-61-6)

Safety Data

• Hazardous Substances Data: 13987-61-6(Hazardous Substances Data)

Usage

Description

TERT-BUTYLAZOMETHINE is an essential compound in synthetic chemistry, known for its role in the synthesis of various pharmaceuticals and organic compounds. It is characterized by its unique chemical structure and reactivity, making it a valuable building block in the development of new drugs and materials.

Uses

Used in Pharmaceutical Synthesis:
TERT-BUTYLAZOMETHINE is used as a key intermediate in the synthesis of GSK369796 (N-tert-Butyl Isoquine), a novel 4-Aminoquinoline antimalarial drug. Its unique chemical properties enable the creation of complex molecular structures, contributing to the development of effective treatments for malaria.
Used in Synthetic Chemistry:
In the field of synthetic chemistry, TERT-BUTYLAZOMETHINE serves as a versatile building block for the creation of a wide range of organic compounds. Its reactivity and structural characteristics make it a valuable asset in the development of new materials and chemical processes.

InChI:InChI=1/C5H11N/c1-5(2,3)6-4/h4H2,1-3H3

Upstream product

• 50-00-0 formaldehyd 
• 75-64-9 tert-butylamine 
• 16479-80-4 2-tert-butyl-oxaziridine 
• 75-18-3 dimethylsulfide 
• 555-16-8 4-nitrobenzaldehdye 
• 52594-52-2 dimethyl(2,2'-bipyridine)platinum(II) 
• 811-98-3 d⁽⁴⁾-methanol 
• 67-56-1 methanol 
• 113776-98-0 1-adamantylidene-1-bromo-2-(tert-butylamino)ethane 
• 113776-99-1 2-adamantylidene-N-tert-butylaziridine 

Downstream Products

• 7153-52-8 4-tert-Butyl-2-(tert-butylamino-methyl)-phenol 
• 53198-37-1 N-(1-Methoxymethyl)-N-nitroso-tert-butylamin 
• 30315-47-0 (R,S)-hydroxymethyl-3-tert-butyl-oxazolidine 
• 140367-33-5 5-tert-Butyl-1,3-diphenyl-[1,3,5]triazinan-2-one 
• 140628-20-2 5-tert-butyl-1-phenylhexahydro-1,3,5-triazine-2-thione 
• 7085-85-0 ethyl-2-cyanoacrilate 
• 2425-74-3 t-butylformamide 
• 108342-66-1 syn-<(tert-Butylnitrosamino)methyl>-3,4-dichlorthiophenolat 
• 92452-75-0 N-Acetyl-S-<(tert-butylnitrosamino)methyl>cystein 
• 82846-52-4 syn-N,N-Diethyldithiocarbamidsaeure-<(tert-butylnitrosamino)methyl>ester 
• 53198-38-2 N-Acetoxymethyl-N-nitroso-tert-butylamin 
• 910578-27-7 2-tert-butylamino-5-(tert-butyl-diphenylacetyl-amino)-furan-3,4-dicarboxylic acid diethyl ester 
• 119011-69-7 (1S,5S)-3-tert-Butyl-6-dimethylamino-1,5-diphenyl-3-aza-bicyclo[3.1.0]hexan-2-one 
• 140628-21-3 5-tert-Butyl-1-(4-methoxy-phenyl)-[1,3,5]triazinane-2-thione 

Relevant articles and documents

A 3-Azacyclopropanespiro-1,2-dioxetane via Singlet Oxygenation of a Methyleneaziridine

The first three-membered ring substituted spiro-1,2-dioxetane (2) has been synthesized and characterized through the singlet oxygenation of methyleneaziridine 1.Thermodynamic properties of the decomposition of 2 are as follows: K20 deg C = 11.5 s-1; Ea = 18.3 kcal/mol; ΔH(excit.) = 17.9 kcal/mol; ΔS(excit.) = 7.5 eu.The chemical properties of this novel dioxetane are compared to those of dioxetanes 11 and 12, dioxetanimine 9, and dioxetanone 10.

Method of preparing electron deficient olefins

This invention relates to a process for producing electron deficient olefins, such as 2-cyanoacrylates, using an iminium salt.

IMINIUM SALTS AND METHODS OF PREPARING ELECTRON DEFICIENT OLEFINS USING SUCH NOVEL IMINIUM SALTS

This invention relates to novel iminium salts, which may be in the form of ionic liquids, and a process for producing electron deficient olefins, such as 2-cyanoacrylates, using such an iminium salt, for instance in the form of an ionic liquid.