139481-58-6 Usage
Description
Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] is a complex organic compound characterized by its unique molecular structure. It is an analog of Candesartan, which is an angiotensin II antagonist. Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] is an off-white solid and is known for its potential applications in various fields due to its chemical properties and interactions.
Uses
Used in Pharmaceutical Industry:
Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] is used as a Candesartan analog for its role as an angiotensin II antagonist. The application reason is that it can potentially help in the treatment of hypertension and heart failure by blocking the effects of angiotensin II, a hormone that narrows blood vessels and increases blood pressure.
Used in Chemical Research:
In the field of chemical research, Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] can be used as a starting material or intermediate for the synthesis of other complex organic compounds. The application reason is its unique molecular structure, which can be further modified or functionalized to create new compounds with specific properties and applications.
Used in Drug Development:
Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] may also be used in drug development as a potential candidate for the treatment of various diseases. The application reason is its ability to act as an angiotensin II antagonist, which could lead to the development of new drugs for hypertension, heart failure, and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 139481-58-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,4,8 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 139481-58:
(8*1)+(7*3)+(6*9)+(5*4)+(4*8)+(3*1)+(2*5)+(1*8)=156
156 % 10 = 6
So 139481-58-6 is a valid CAS Registry Number.
139481-58-6Relevant articles and documents
METHOD FOR PREPARING TRITYL CANDESARTAN
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Paragraph 0031-0034, (2018/06/15)
The present invention uses a candesartan cyclic compound as a starting material and performs thereon a three-step reaction of forming tetrazole, hydrolysis and adding a protecting group to directly obtain trityl candesartan without separating an intermediate product via crystallization. The operating process is simple and thus is more applicable to industrial production.
METHOD FOR OBTAINING BENZIMIDAZOLE DERIVATIVES AND INTERMEDIATES THEREOF
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Page/Page column 20, (2010/11/25)
The present invention relates to a method for obtaining benzimizadole derivatives and intermediates thereof, preferably, for obtaining Candesartan and Candesartan cilexetil. Said method allows the benzimizadole derivatives to be obtained with a higher yield.
1-(CYCLOHEXYLOXYCARBONYLOXY)ETHYL 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL]BENZIMIDAZOLE-7-CARBOXYLATE AND COMPOSITIONS AND METHODS OF PHARMACEUTICAL USE THEREOF
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, (2008/06/13)
1-(Cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1 H-tetrazol-5-y l)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.