1392131-52-0

Basic information

• Product Name: 1-(2-bromo-5-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea
• Synonyms: 1-(2-bromo-5-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea
• CAS NO: 1392131-52-0
• Molecular Weight: 405.678
• Mol File: 1392131-52-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-5-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-5-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea(1392131-52-0)
• EPA Substance Registry System: 1-(2-bromo-5-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea(1392131-52-0)

Safety Data

• Hazardous Substances Data: 1392131-52-0(Hazardous Substances Data)

Upstream product

• 27006-83-3 1,3-dimethyl-5-chloro-pyrazole-4-carbonyl chloride 
• 27006-82-2 5-chloro-1,3-dimethyl-4-pyrazolecarboxylic acid 
• 27006-76-4 5-chloro-4-formyl-1,3-dimethylpyrazole 
• 2749-59-9 1,3-dimethyl-5-pyrazolone 
• 357204-44-5 C₇H₆ClN₃OS 
• 1003-99-2 2-bromo-5-fluoroaniline 

Relevant articles and documents

Synthesis and bioactivity of pyrazole acyl thiourea derivatives

Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3- methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate in the presence of PEG-400 to afford 5-chloro-3- methyl -1-substituted-1H-pyrazole-4-carbonyl isothiocyanates 5. Subsequent reaction with fluorinated aromatic amines resulted in the formation of the title compounds. The synthesized compound were unequivocally characterized by IR, 1H-NMR, 13C-NMR and elemental analysis and some of the synthesized compounds displayed good antifungal activities against Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica and anti-TMV activity in preliminary antifungal activity tests.