1391034-95-9

Basic information

• Product Name: phenethyl ether 7'-aminonaltrindole
• Synonyms: phenethyl ether 7'-aminonaltrindole
• CAS NO: 1391034-95-9
• Molecular Weight: 533.67
• Mol File: 1391034-95-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phenethyl ether 7'-aminonaltrindole(CAS DataBase Reference)
• NIST Chemistry Reference: phenethyl ether 7'-aminonaltrindole(1391034-95-9)
• EPA Substance Registry System: phenethyl ether 7'-aminonaltrindole(1391034-95-9)

Safety Data

• Hazardous Substances Data: 1391034-95-9(Hazardous Substances Data)

Upstream product

• 1391034-98-2 phenethyl ether 7'-nitronaltrindole 
• 103-63-9 1-phenyl-2-bromoethane 
• 16676-29-2 naltrexone Hydrochloride 
• 3034-19-3 (2-nitrophenyl)hydrazine 

Downstream Products

• 1391034-99-3 C₃₈H₃₉N₃O₇ 

Relevant articles and documents

Tuned-affinity bivalent ligands for the characterization of opioid receptor heteromers

Opioid receptors, including the μ- and δ-opioid receptors (MOR and DOR), are important targets for the treatment of pain. Although there is mounting evidence that these receptors form heteromers, the functional role of the MOR/DOR heteromer remains unresolved. We have designed and synthesized bivalent ligands as tools to elucidate the functional role of the MOR/DOR heteromer. Our ligands (L2 and L4) are comprised of a compound with low affinity at the DOR tethered to a compound with high affinity at the MOR, with the goal of producing ligands with "tuned affinity" at MOR/DOR heteromers as compared to DOR homomers. Here, we show that both L2 and L4 demonstrate enhanced affinity at MOR/DOR heteromers as compared to DOR homomers, thereby providing unique pharmacological tools to dissect the role of the MOR/DOR heteromer in pain.