1385829-31-1

Basic information

• Product Name: 2-{4-[4-(2-methylthiazol-4-yl)phenethyl]piperazin-1-yl}quinoxaline
• CAS NO: 1385829-31-1
• Molecular Weight: 415.562
• Mol File: 1385829-31-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{4-[4-(2-methylthiazol-4-yl)phenethyl]piperazin-1-yl}quinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{4-[4-(2-methylthiazol-4-yl)phenethyl]piperazin-1-yl}quinoxaline(1385829-31-1)
• EPA Substance Registry System: 2-{4-[4-(2-methylthiazol-4-yl)phenethyl]piperazin-1-yl}quinoxaline(1385829-31-1)

Safety Data

• Hazardous Substances Data: 1385829-31-1(Hazardous Substances Data)

Upstream product

• 777816-91-8 C₁₂H₁₂ClNS 
• 55686-91-4 2-(1-piperazinyl)-quinoxaline 
• 622-24-2 2-phenylethyl chloride 
• 129865-49-2 C₁₀H₁₀Cl₂O 
• 95-54-5 1,2-diamino-benzene 
• 1196-57-2 2-hydroxyquinoxaline 

Relevant articles and documents

Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl] phenyl}thiazoles as atypical antipsychotic agents

A series of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl] phenyl} thiazoles were synthesized in an effort to prepare novel atypical antipsychotic agents. The compounds were designed, synthesized, and characterized by spectral data (IR, 1H NMR, and MS) and the purity was ascertained by microanalysis. The D2 and 5-HT2A affinity of the synthesized compounds was screened in vitro by radioligand displacement assays on membrane homogenates isolated from rat striatum and rat cortex, respectively. Furthermore, all the synthesized final compounds (10a-g; 11a-g; 12a-g) were screened for their in vivo pharmacological activity in Swiss albino mice. D2 antagonism studies were performed using climbing mouse assay model and 5-HT2A antagonism studies were performed using quipazine-induced head twitches in mice. It was observed that none of the new chemical entities exhibited catalepsy and 12d, 11f, and 10a were found to be the most active compounds with 5-HT2A/D2 ratio of 1.23077, 1.14286, and 1.12857, respectively, while the standard drug risperidone exhibited 5-HT2A/D2 ratio of 1.0989. Among the twenty one new chemical entities, three compounds (12d, 11f, and 10a) were found to exhibit better atypical antipsychotic activity as they were found to have higher Meltzer index than the standard drug risperidone.