13850-91-4Relevant articles and documents
Solution-phase synthesis and biological evaluation of triostin A and its analogues
Hattori, Kozo,Koike, Kota,Okuda, Kensuke,Hirayama, Tasuku,Ebihara, Masahiro,Takenaka, Mei,Nagasawa, Hideko
, p. 2090 - 2111 (2016)
Triostin A is a biosynthetic precursor of echinomycin which is one of the most potent hypoxia inducible factor 1 (HIF-1) inhibitors. An improved solution-phase synthesis of triostin A on a preparative scale has been achieved in 17.5% total yield in 13 ste
Chemical mediators: The remarkable structure and host-selectivity of depsilairdin, a sesquiterpenic depsipeptide containing a new amino acid
Pedras, M. Soledade C.,Chumala, Paulos B.,Wilson Quail
, p. 4615 - 4617 (2004)
(Chemical equation presented) The chemical structure determination of depsilairdin, a highly selective phytotoxin produced by the plant pathogenic fungus Leptosphaeria maculans/Phoma lingam, is described. The elucidation of the unusual chemical structure
Cytotoxic peptides from the marine sponge Cymbastela sp.
Coleman, John E.,Dilip De Silva,Kong, Fangming,Andersen, Raymond J.,Allen, Theresa M.
, p. 10653 - 10662 (1995)
Extracts of the sponge Cymbastela sp. have yielded the novel cytotoxic peptides geodiamolide G (11), hemiasterlin (12), hemiasterlin B (13), criamide A (14) and criamide B (15). The structures of the new compounds were solved via spectroscopic analysis and chemical degradation.
Design, SAR, angiogenic activities evaluation and pro-angiogenic mechanism of new marine cyclopeptide analogs
Li,Lu,Wu,Yu,Xu,Qiu,Pei,Lin,Pang
, p. 1183 - 1194 (2013/07/28)
Angiogenesis plays an important role in a wide range of physiological processes. In this paper, we designed and synthesized a series of new analogs including 11 line-peptides and 9 cyclo-peptides by using a marine cyclopeptide (compound 21) which could st