1383422-53-4Relevant articles and documents
Electrochemical Decarboxylative N-Alkylation of Heterocycles
Baran, Phil. S.,He, Chi,Shang, Ming,Sheng, Tao,Vantourout, Julien. C.,Zhang, Hai-Jun
supporting information, p. 7594 - 7598 (2020/10/09)
An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.