1380432-32-5 Usage
Description
N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine is a complex organic compound with a unique molecular structure that features a carbazole and morpholine moiety. N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine is characterized by its potential applications in various fields due to its distinct chemical properties and interactions.
Uses
Used in Pharmaceutical Industry:
N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine is used as an EHop inhibitor for studying signaling diversity during Chlamydia trachomatis cell entry. It plays a crucial role in understanding the molecular mechanisms involved in the infection process and may contribute to the development of novel therapeutic strategies against this bacterial pathogen.
N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine is also used as a RAC inhibitor, which can be applied in the research and development of treatments for various diseases, including cancer. By inhibiting the activity of Rac1 and Rac3, this compound can potentially interfere with the signaling pathways that promote cell migration and tumor growth, making it a valuable tool in the fight against cancer.
Additionally, N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine has been shown to increase Rho GTPase RhoA activity at concentrations greater than 2 μM, which may have implications in the study and treatment of various diseases related to RhoA signaling.
Biochem/physiol Actions
EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. EHop-016 inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation.
Check Digit Verification of cas no
The CAS Registry Mumber 1380432-32-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,0,4,3 and 2 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1380432-32:
(9*1)+(8*3)+(7*8)+(6*0)+(5*4)+(4*3)+(3*2)+(2*3)+(1*2)=135
135 % 10 = 5
So 1380432-32-5 is a valid CAS Registry Number.
1380432-32-5Relevant articles and documents
NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTI-CANCER AND ANTI-MIGRATORY AGENTS
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, (2019/05/15)
A series of novel of EHop-016 derivatives is presented herein via designing and synthesizing compounds that mimics its more favorable “U-shaped” conformation that appears to be critical for inhibitory activity against Rac. Based on modeling studies on EHop-016, compounds with a more rigid structural conformation can mimic this “U-shaped” conformation would improve the anti-migration activity against metastatic cells. Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed.
