137988-23-9

Basic information

• Product Name: Acetonitrile, (2-fluorophenoxy)- (9CI)
• Synonyms: Acetonitrile, (2-fluorophenoxy)- (9CI);2-(2-Fluorophenoxy)-acetonitrile
• CAS NO: 137988-23-9
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.1377432
• Product Categories: HALIDE
• Mol File: 137988-23-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetonitrile, (2-fluorophenoxy)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetonitrile, (2-fluorophenoxy)- (9CI)(137988-23-9)
• EPA Substance Registry System: Acetonitrile, (2-fluorophenoxy)- (9CI)(137988-23-9)

Safety Data

• Hazardous Substances Data: 137988-23-9(Hazardous Substances Data)

Usage

General Description

Acetonitrile, (2-fluorophenoxy)- (9CI) is a chemical compound with the molecular formula C8H6FN. It is a colorless liquid with a faint odor and is commonly used as a solvent in various chemical processes, including pharmaceutical manufacturing, extraction processes, and in the production of various chemicals. It is also used as a starting material for the synthesis of other compounds. Acetonitrile, (2-fluorophenoxy)- (9CI) has potential health hazards and should be handled and used with caution in a well-ventilated area, with appropriate personal protective equipment. It is important to follow all safety guidelines and regulations when working with this chemical compound.

Upstream product

• 367-12-4 2-fluorophenol 
• 590-17-0 cyanomethyl bromide 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 1532533-94-0 2-(2-fluorophenoxy)-1-(2,4,6-trihydroxyphenyl)ethanone 
• 137987-82-7 1-(2,4-dihydroxyphenyl)-2-(2-fluorophenoxy)ethanone 
• 1532534-17-0 1-(2,4-dihydroxy-5-methylphenyl)-2-(2-fluorophenoxy)ethanone 
• 1532534-42-1 C₁₇H₁₇FO₄ 
• 729-79-3 C-<2-Fluor-phenoxy>-acetanilid 
• 137988-08-0 Acetic acid 3-(2-fluoro-phenoxy)-4-oxo-4H-chromen-7-yl ester 
• 137374-74-4 3-(2-Fluoro-phenoxy)-7-hydroxy-chromen-4-one 

Relevant articles and documents

Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa

Antibiotic resistance coupled with decreased development of new antibiotics necessitates the search for novel antibacterial agents. Antivirulence agents offer an alternative to conventional antibiotics. In this work, we report on a family of small-molecule antivirulence agents against methicillin-resistant Staphylococcus aureus (MRSA), the most widespread bacterial pathogen. Structure-activity relationship studies led to the development of a concise synthesis of a 148-member biarylhydroxyketone library. An acylation bond-forming process afforded resorcinols (1) and aryloxy acetonitriles (2) as synthons. A Lewis-acid-activated Friedel-Crafts' acylation step involving a nitrile functionality of 2 by ZnCl2, followed by nucleophilic attack by 1 was executed to obtain biaryl hydroxyketones in excellent yields. A large number of products crystallized. This strategy affords a range of biarylhydroxyketones in a single step. This is the first collective synthetic study documenting access to this class of compounds through a single synthetic operation. In vitro efficacy of compounds in this library was evaluated by a rabbit erythrocyte hemolysis assay. The most efficacious compound, 4f-12, inhibits hemolysis by 98.1 ± 0.1% compared to control in the absence of the compound.

POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES

A medicament for therapeutic and/or preventive treatment of a brain disease, which comprises a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein R represents hydrogen atom, a C1-C8 alkyl group, a substituted C1-C8 alkyl group, an aryl group, a substituted aryl group, an aryl(C1-C8)alkyl group and the like; Y represents hydrogen atom or -C(R2)R3 (R2 and R3 represent hydrogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy(C1-C8)alkyl group, a hydroxy(C1-C8)alkyl group and the like); symbol "a" represents single bond when Y represents hydrogen atom, or "a" represents double bound when Y represents -C(R2)R3; -A-B- represents -CH2-CH2-, -S-CH2-, -O-CH2-, -CH2-S-, -CH2-O-, -SO-CH2-, -CH2-SO-, -SO2-CH2-, or -CH2-SO2-; and Z represents -CH2- or single bond.