1378531-80-6

Basic information

• Product Name: DBCO-PEG5-NHS ester
• Synonyms: DBCO-PEG5-NHS ester;Azadibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester;DBCO-NH-PEG4-CH2CH2COONHS ester
• CAS NO: 1378531-80-6
• Molecular Formula: C₃₆H₄₃N₃O₁₁
• Molecular Weight: 693.74012
• Mol File: 1378531-80-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• PKA: 15.14±0.46(Predicted)
• CAS DataBase Reference: DBCO-PEG5-NHS ester(CAS DataBase Reference)
• NIST Chemistry Reference: DBCO-PEG5-NHS ester(1378531-80-6)
• EPA Substance Registry System: DBCO-PEG5-NHS ester(1378531-80-6)

Safety Data

• Hazardous Substances Data: 1378531-80-6(Hazardous Substances Data)

Usage

Description

DBCO-PEG5-NHS ester is a PEG linker containing an NHS ester that can specifically and efficiently react with primary amines, such as the side chain of lysine residues or aminosilane-coated surfaces, under neutral or slightly basic conditions to form a covalent bond. The hydrophilic PEG spacer arm enhances water solubility and provides a long, flexible connection that minimizes steric hindrance during ligation. DBCO is commonly utilized in copper-free Click Chemistry reactions.

Uses

Used in Bioconjugation:
DBCO-PEG5-NHS ester is used as a bioconjugation agent for the formation of covalent bonds between primary amines and the PEG linker. This application is particularly useful in the creation of stable and well-defined bioconjugates with minimal steric hindrance.
Used in Drug Delivery Systems:
In the pharmaceutical industry, DBCO-PEG5-NHS ester is used as a component in drug delivery systems for improving the solubility and bioavailability of therapeutic molecules. The PEG spacer arm can enhance the stability and circulation time of drug molecules in the body.
Used in Diagnostics:
In the diagnostics industry, DBCO-PEG5-NHS ester is used as a component in the development of imaging agents and biosensors. The PEG linker can help improve the solubility and biocompatibility of these diagnostic tools, leading to better performance and accuracy.
Used in Material Science:
In the field of material science, DBCO-PEG5-NHS ester is used as a component in the synthesis of functional materials, such as hydrogels and self-assembled nanostructures. The PEG linker can provide improved water solubility and flexibility, which can be beneficial for the properties and performance of these materials.
Used in Chemical Biology:
In chemical biology research, DBCO-PEG5-NHS ester is used as a tool for the specific and efficient conjugation of biomolecules, such as proteins, peptides, and nucleic acids. The PEG linker can help improve the stability and solubility of these biomolecules, facilitating their study and potential applications in various biological processes.

Downstream Products

• 1415001-60-3 C₆₀H₈₁N₁₁O₁₅ 
• 1415001-59-0 C₅₉H₇₉N₁₁O₁₅