137-06-4 Usage
Description
2-Methylbenzenethiol, also known as 2-Methylthiophenol or o-toluenethiol, is a clear colorless to slightly yellow-brown liquid with a disagreeable odor. It is an organic compound that belongs to the class of thiols, characterized by the presence of a sulfur-hydrogen bond. It has been reported to be found in coffee and is known for its meaty, onion, garlic, chemical, and metallic taste characteristics at a concentration of 4 ppm.
Uses
Used in Pharmaceutical Industry:
2-Methylbenzenethiol is used as a reagent for molecular modeling and the preparation of 4-hydroxy-5,6-dihydropyrones, which are inhibitors of HIV protease. This application is significant in the development of antiretroviral drugs to combat the HIV virus.
Used in Agriculture:
In the agricultural sector, 2-Methylbenzenethiol is utilized for its fungicidal and inhibitory activity against Histoplasma capsulatum, a fungus that can cause severe respiratory infections in humans and animals. Its use helps in controlling the spread of this fungus and protecting crops from potential damage.
Used in Flavor and Fragrance Industry:
Due to its distinct taste characteristics, 2-Methylbenzenethiol can be used as a flavoring agent in the food and beverage industry, particularly for enhancing the meaty, onion, and garlic flavors in various products. Additionally, its unique odor can be employed in the fragrance industry for creating specific scents and perfumes.
Used in Chemical Research:
As an organic compound, 2-Methylbenzenethiol can be used in chemical research for studying the properties and reactions of thiols. This can contribute to the development of new chemical processes and the synthesis of novel compounds with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 137-06-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 137-06:
(5*1)+(4*3)+(3*7)+(2*0)+(1*6)=44
44 % 10 = 4
So 137-06-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H8S/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3/p-1
137-06-4Relevant articles and documents
The aromatic thiol compound (by machine translation)
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Paragraph 0083, (2017/10/31)
[A] at a high rate, and, high purity aromatic thiol compound method. [Solution] the presence of metal sulfide, with a compound represented by formula (1), by a vapor phase reaction of hydrogen sulfide, (2) an aromatic thiol compound represented by the formula manufacturing method. (R are each independently, C1 a-4 alkyl group, a hydroxyl group, amino group, cyano group, nitro group, C1 a-2 alkoxy group or a halogen atom; n is an integer of 0 - 5; X is a halogen atom)[Drawing] no (by machine translation)
SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF
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Paragraph 0032; 0033; 0063; 0067; 0068; 0070; 0103, (2017/09/02)
The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017
Palladium catalyzed synthesis of aryl thiols: Sodium thiosulfate as a cheap and nontoxic mercapto surrogate
Yi, Jun,Fu, Yao,Xiao, Bin,Cui, Wei-Chen,Guo, Qing-Xiang
experimental part, p. 205 - 208 (2011/02/26)
A Pd-catalyzed coupling reaction of ArBr/ArCl/ArOTf with sodium thiosulfate takes place in presence of Cs2CO3 at 80 °C. The reaction mixture is directly treated with Zn/HCl to afford aryl thiols in good to excellent yields.