1367905-79-0

Basic information

• Product Name: 5-broMo-2-Methylisoquinolin-1(2H)-one
• Synonyms: 5-broMo-2-Methylisoquinolin-1(2H)-one;5-bromo-2-methyl-1,2-dihydroisoquinolin-1-one
• CAS NO: 1367905-79-0
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.08062
• Mol File: 1367905-79-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 373.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.553±0.06 g/cm3(Predicted)
• PKA: -2.67±0.70(Predicted)
• CAS DataBase Reference: 5-broMo-2-Methylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-2-Methylisoquinolin-1(2H)-one(1367905-79-0)
• EPA Substance Registry System: 5-broMo-2-Methylisoquinolin-1(2H)-one(1367905-79-0)

Safety Data

• Hazardous Substances Data: 1367905-79-0(Hazardous Substances Data)

Usage

Description

5-Bromo-2-methylisoquinolin-1(2H)-one, also known as BMIO, is a chemical compound with a molecular formula of C10H8BrNO. It is a derivative of isoquinolin-1(2H)-one, a heterocyclic compound. BMIO is a pale-yellow solid that is sparingly soluble in water and has a melting point of 193-194°C. Its unique structure and properties make it a valuable building block for the synthesis of biologically active molecules.

Uses

Used in Organic Chemistry:
5-Bromo-2-methylisoquinolin-1(2H)-one is used as a reagent in organic chemistry for its versatile reactions in various synthesis processes.
Used in Pharmaceutical Applications:
5-Bromo-2-methylisoquinolin-1(2H)-one is used as a building block in the development of new drugs and medicinal compounds due to its potential in pharmaceutical applications.

Upstream product

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• 1109230-25-2 5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one 
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Relevant articles and documents

Visible-Light-Mediated Aerobic Oxidation of N-Alkylpyridinium Salts under Organic Photocatalysis

Quinolones and isoquinolones exhibit diverse biological and pharmaceutical activities, and their synthesis is highly desirable under mild conditions. Here, a highly efficient and environmentally friendly visible light-mediated aerobic oxidation of readily available N-alkylpyridinium salts has been developed with Eosin Y as the organic photocatalyst and air as the terminal oxidant, and the reaction provided quinolones and isoquinolones in good yields. The method shows numerous advantages including mild and environmentally friendly conditions, high efficiency, tolerance of wide functional groups and low cost. Furthermore, 4-desoxylonimide with important pharmaceutical activities was effectively prepared by using our method. Therefore, the present method should provide a novel and useful strategy for synthesis and modification of N-heterocycles.

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

CARBAZOLE COMPOUNDS AND METHODS OF USING SAME

The present invention provides carbazole compounds of the formula (I), which can be used for treating microbial, protozoan, viral infections and cancer. ?