13609-67-1 Usage
Description
Hydrocortisone-17-butyrate, also known as Hydrocortisone Butyrate, is a cortisol esterified with butyric acid at the 17-hydroxy group. It is a synthetic corticosteroid that possesses anti-inflammatory, antiproliferative, and immunosuppressive properties. Hydrocortisone-17-butyrate is commonly used in the treatment of various dermatological conditions and is also recognized as a marker for topical corticosteroid allergy.
Uses
Used in Dermatology:
Hydrocortisone-17-butyrate is used as a topical corticosteroid for the treatment of various dermatological conditions. It acts as an anti-inflammatory, antiproliferative, and immunosuppressive agent, helping to alleviate inflammation, reduce the risk of skin cell overgrowth, and suppress the immune response in the affected area.
Used in Allergy Testing:
Hydrocortisone-17-butyrate is used as a marker for topical corticosteroid allergy. This application aids in identifying individuals who may have an allergic reaction to corticosteroids, which is crucial for determining the appropriate treatment options for their dermatological conditions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Hydrocortisone-17-butyrate is used as an active ingredient in various topical formulations, such as creams, ointments, and lotions. These formulations are designed to provide targeted relief for skin conditions like eczema, psoriasis, and contact dermatitis.
Brand Names:
Some of the brand names under which Hydrocortisone-17-butyrate is marketed include Locoid (Ferndale) and Locoid (Yamanouchi). These products are widely recognized and trusted for their effectiveness in managing various skin conditions.
Biochem/physiol Actions
Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.
Contact allergens
Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti-
sone. It represents the D2 group of corticosteroids, non
C 16 methylated with a C 17 ester: hydrocortisone
17-butyrate, hydrocortisone 17-valerate, hydrocortisone
aceponate (17-propionate and 21-acetate), methylpred-
nisolone aceponate, and prednicarbate. It is sometimes
hydrolyzed in vivo into hydrocortisone, giving allergic
reactions to group-A-sensitized people.
Check Digit Verification of cas no
The CAS Registry Mumber 13609-67-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,6,0 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13609-67:
(7*1)+(6*3)+(5*6)+(4*0)+(3*9)+(2*6)+(1*7)=101
101 % 10 = 1
So 13609-67-1 is a valid CAS Registry Number.
InChI:InChI=1/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18?,19-,22?,23-,24-,25-/m0/s1
13609-67-1Relevant articles and documents
An improved synthesis of corticosteroid 17α-esters by synthetic aluminium silicate-mediated conversion of 17α, 21-cyclic ortho esters
Sugai,Okazaki,Akaboshi
, p. 700 - 701 (1984)
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Composition for the topical treatment of poison ivy and other forms of contact dermatitis
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, (2008/06/13)
Composition for topical administration comprising (a) a corticosteroid, and (b) a drying agent.