136-95-8Relevant articles and documents
Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles
Chen, Xiran,Fu, Lianrong,Hao, Xin-Qi,Shi, Linlin,Song, Mao-Ping,Zhu, Xinju,Zhu, Yu-Shen
, (2021/09/09)
A facile and sustainable approach for the amination of benzothiazoles with KSeCN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles
Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction
-
Paragraph 0111-0118; 0121, (2021/05/29)
The invention provides a ligand compound capable of being used for copper catalyzed aryl halide coupling reaction, the ligand compound is a three-class compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group, and the invention also provides a catalytic system for the aryl halide coupling reaction. Thecatalytic system comprises a copper catalyst, a compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group adopted as a ligand, alkali and a solvent, and meanwhile, the invention also provides a system for the aryl halide coupling reaction adopting the catalyst system. The compound containing the 2-(substituted or non-substituted) aminopyridine nitrogen oxygen group can be used as the ligand for the copper catalyzed aryl chloride coupling reaction, and the ligand is stable under a strong alkaline condition and can well maintain catalytic activity when being used for the copper-catalyzed aryl chloride coupling reaction. In addition, the copper catalyst adopting the compound as the ligand can particularly effectively promote coupling of copper catalyzed aryl chloride and various nucleophilic reagents which are difficult to generate under conventional conditions, C-N, C-O and C-S bonds are generated, and numerous useful small molecule compounds are synthesized. Therefore, the aryl halide coupling reaction has a very good large-scale application prospect by adopting the copper catalysis system of the ligand.
Synthesis and photophysical investigation of (BTHN) Schiff base as off-on Cd2+ fluorescent chemosensor and its live cell imaging
Khan, Salman A.,Ullah, Qasim,Almalki, Abdulraheem S.A.,Kumar, Sanjay,Obaid, Rami J.,Alsharif, Meshari A.,Alfaifi,Hashmi, Authar Adil
, (2021/02/05)
A Schiff base, 1-[2-(1,3-benzothiazol-2-yl)hydrazinylidene]methyl-naphthalen-2-ol (BTHN) have been synthesized by the condensation of 2-hydrazinobenzothiazole and 2-hydroxy-1-naphthaldehyde. Structure of BTHN has been determined with the help of spectroscopic techniques and elemental analysis. Photophysical parameters of the BTHN were studied in the different solvents of varying polarity. The photophysical parameter were largely affected by the varying polarity and absorption as well as emission spectra showed strong bathochromic shift. Further, interactions of the BTHN dye with metal ions were also explored by spectrofluorimetry and BTHN found to be an excellent off-on chemosensor for Cd2+ in DMF-H2O solution. The molecular coordination complex between BTHN with Cd2+ is 1:1, confirmed by Benesi-Hildebrand and Job-plot method. In addition, the BTHN has been effectively employed for the fluorescence imaging of cadmium ions in the living cells.