13577-19-0

Basic information

• Product Name: 8-IODO-1-NAPHTHOIC ACID
• Synonyms: 8-IODO-1-NAPHTHOIC ACID;8-IODONAPHTHOIC ACID;8-Iodo-1-naphthalenecarboxylic acid
• CAS NO: 13577-19-0
• Molecular Formula: C₁₁H₇IO₂
• Molecular Weight: 298.08
• Product Categories: Naphthalene derivatives;Carboxylic Acids;Carboxylic Acids;Fused Ring Systems
• Mol File: 13577-19-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 164.5℃
• Boiling Point: 442.3°Cat760mmHg
• Flash Point: 221.3°C
• Appearance: /
• Density: 1.884g/cm³
• Vapor Pressure: 1.33E-08mmHg at 25°C
• Refractive Index: 1.742
• PKA: 2.24±0.10(Predicted)
• CAS DataBase Reference: 8-IODO-1-NAPHTHOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 8-IODO-1-NAPHTHOIC ACID(13577-19-0)
• EPA Substance Registry System: 8-IODO-1-NAPHTHOIC ACID(13577-19-0)

Safety Data

• Hazardous Substances Data: 13577-19-0(Hazardous Substances Data)

Usage

General Description

8-Iodo-1-naphthoic acid is a chemical compound that belongs to the family of naphthalene derivatives, which are widely used in the pharmaceutical and organic synthesis industries. It is a white to pale yellow powder that is generally stable under normal conditions. 8-IODO-1-NAPHTHOIC ACID is known for its reactivity and is often used as a building block in the synthesis of various pharmaceuticals and organic compounds. It is also commonly used as an intermediate in the production of dyes, pigments, and other industrial chemicals. The presence of the iodine substituent in its structure gives it unique properties and reactivity, making it valuable in a range of chemical processes and applications.

InChI:InChI=1/C11H7IO2/c12-9-6-2-4-7-3-1-5-8(10(7)9)11(13)14/h1-6H,(H,13,14)

Upstream product

• 81-84-5 1,8-Naphthalic anhydride 
• 518-05-8 Naphthalene-1,8-dicarboxylic acid 
• 6314-27-8 O-(hydroxymercuri)-1-naphtoic acid anhydride 
• 130-00-7 1,8-naphtholactam 
• 129-02-2 8-amino-[1]naphthoic acid 

Downstream Products

• 85864-85-3 methyl 8-iodo-1-naphthoate 
• 131073-73-9 2-(8-Carboxy-1-naphthylthio)benzoic acid 
• 52753-62-5 1-amino-8-iodonaphthalene 
• 1366068-23-6 JWH-417 
• 1366068-19-0 JWH-416 
• 131073-65-9 (+/-)-2-(8-carboxy-1-naphthylsulfinyl)benzoic acid 
• 108060-48-6 2-(8-Acetyl-1-naphthylthio)benzoesaeure-methylester 
• 191404-57-6 8-[2-(hydroxymethyl)-1-phenylsulfinyl]-1-naphthoic acid 
• 163628-74-8 8-{4-[(E)-2-(2,2,2-Trichloro-ethoxycarbonyl)-vinyl]-phenyl}-naphthalene-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 163628-73-7 8-(4-Formyl-phenyl)-naphthalene-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 163628-75-9 8-[4-((E)-2-Carboxy-vinyl)-phenyl]-naphthalene-1-carboxylic acid 
• 191404-55-4 8-[2-(hydroxymethyl)-1-phenylthio]-1-naphthoic acid 
• 163070-75-5 8-{4-[2-(Tetrahydro-pyran-2-yloxy)-ethyl]-phenyl}-naphthalene-1-carbonitrile 
• 163070-77-7 8-<4-(2-Hydroxyethyl)phenyl>naphthalin-1-carboxamidoxim 

Relevant articles and documents

Synthesis and photophysical properties of a porphyrin-perinaphthothioindigo dye

A new porphyrin-perinaphthothioindigo composite, where porphyrin and perinaphthothioindigo dye are connected though a triple bond, was synthesized. In UV-vis absorption spectra of the composite, absorption originating from the trans-isomer appeared at 655

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Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents

To develop SAR at both the cannabinoid CB1 and CB2 receptors for 3-(1-naphthoyl)indoles bearing moderately electron withdrawing substituents at C-4 of the naphthoyl moiety, 1-propyl and 1-pentyl-3-(4-fluoro, chloro, bromo and iodo-1-naphthoyl) derivatives were prepared. To study the steric and electronic effects of substituents at the 8-position of the naphthoyl group, the 3-(4-chloro, bromo and iodo-1-naphthoyl)indoles were also synthesized. The affinities of both groups of compounds for the CB1 and CB2 receptors were determined and several of them were evaluated in vivo in the mouse. The effects of these substituents on receptor affinities and in vivo activity are discussed and structure-activity relationships are presented. Although many of these compounds are selective for the CB2 receptor, only three JWH-423, 1-propyl-3-(4-iodo-1-naphthoyl)indole, JWH-422, 2-methyl-1-propyl-3-(4-iodo-1-naphthoyl)indole, the 2-methyl analog of JWH-423 and JWH-417, 1-pentyl-3-(8-iodo-1-naphthoyl)indole, possess the desirable combination of low CB1 affinity and good CB2 affinity.

Synthesis of 2-hydroxy-8′-(hydroxymethyl)-1,1′-binaphthalene (iso-homo-binol). A new structural pattern in the binaphthyl realm

The title compound 7 has been synthesized in a racemic form, using Suzuki coupling (8 + 15 → 16) as the key step. Pure enantiomer (S)-(-)-7 has been obtained by carbonylation of the known bromide (S)-(+)-12 followed by reduction of the resulting methyl ester (S)-(+)-18 with LiAlH4.