1354900-66-5

Basic information

• Product Name: Oxazolidine CAB
• Synonyms: (4S,5R)-2-(4-Methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylic acid 5-[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl] 3-(1,1-dimethylethyl) ester
• CAS NO: 1354900-66-5
• Molecular Formula: C₅₃H₆₃NO₁₅
• Molecular Weight: 954.07
• Mol File: 1354900-66-5.mol
• Article Data: 2

Chemical Properties

• Density: 1.32±0.1 g/cm3 (20 ºC 760 Torr), Calc.*
• CAS DataBase Reference: Oxazolidine CAB(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazolidine CAB(1354900-66-5)
• EPA Substance Registry System: Oxazolidine CAB(1354900-66-5)

Safety Data

• Hazardous Substances Data: 1354900-66-5(Hazardous Substances Data)

Usage

General Description

Oxazolidine CAB is a chemical compound that is commonly used as a coalescing agent in water-based coatings and adhesives. Its main function is to facilitate the formation of a continuous film by lowering the minimum film-forming temperature and enhancing the adhesion of the coating or adhesive to the substrate. Oxazolidine CAB also acts as a crosslinking agent, improving the mechanical and chemical properties of the final coating or adhesive. Additionally, it is known for its low volatility and relatively low toxicity, making it a preferred choice for environmentally-friendly formulations. Overall, Oxazolidine CAB plays a crucial role in improving the performance and versatility of water-based coatings and adhesives.

Upstream product

• 95603-44-4 7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III 
• 859498-31-0 C₅₇H₆₁Cl₆NO₁₉ 
• 67-56-1 methanol 
• 1354900-65-4 cabazitaxel 
• 160084-70-8 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 
• 32981-86-5 10-deacetylbaccatin III 
• 74-88-4 methyl iodide 

Downstream Products

• 114915-20-7 Docetaxel 
• 183133-96-2 carbazitaxel 

Relevant articles and documents

Preparation method of cabazitaxel

The invention discloses a preparation method of cabazitaxel, which comprises the following specific steps: dissolving 10-deacetylbaccatin III with dichloromethane and pyridine, dropwise adding 2,2,2-trichloroethyl chloroformate, and treating to obtain an intermediate I; mixing toluene, 4-dimethylaminopyridine, the intermediate I and (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)- 4-phenyl-5-oxazolidinecarboxylic acid, stirring, dropwise adding N,N'-dicyclohexylcarbodiimide, and stirring for reaction to obtain an intermediate II; dissolving the intermediate II with ethyl acetate and acetic acid, adding zinc powder, carrying out a stirring reaction to obtain an intermediate III, dissolving the intermediate III with dichloromethane, adding 1,8-bis(dimethylamino)naphthalene, a molecular sieve and trimethyloxonium tetrafluoroborate, and carrying out a stirring reaction to obtain an intermediate IV; dissolving and clarifying the intermediate IV with methanol, dropwise adding a hydrochloric acid methanol solution having a concentration of 1mol/L, and stirring for reaction to obtain cabazitaxel. According to the method, methylation can be realized at room temperature, the product purity is good, the yield is high, starting materials are easy to obtain, and large-scale preparation can be carried out.