1353040-43-3

Basic information

• Product Name: 2-chloro-9-(3',5'-di-O-benzoyl-2'-O-trifluoromethylsulfonyl-β-D-ribofuranosyl)adenine
• Synonyms: 2-chloro-9-(3',5'-di-O-benzoyl-2'-O-trifluoromethylsulfonyl-β-D-ribofuranosyl)adenine
• CAS NO: 1353040-43-3
• Molecular Weight: 641.969
• Mol File: 1353040-43-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-9-(3',5'-di-O-benzoyl-2'-O-trifluoromethylsulfonyl-β-D-ribofuranosyl)adenine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-9-(3',5'-di-O-benzoyl-2'-O-trifluoromethylsulfonyl-β-D-ribofuranosyl)adenine(1353040-43-3)
• EPA Substance Registry System: 2-chloro-9-(3',5'-di-O-benzoyl-2'-O-trifluoromethylsulfonyl-β-D-ribofuranosyl)adenine(1353040-43-3)

Safety Data

• Hazardous Substances Data: 1353040-43-3(Hazardous Substances Data)

Upstream product

• 58-96-8 uridine 
• 118-00-3 G 
• 146-77-0 2-Chloroadenosine 
• 1055168-98-3 6-amino-2-chloro-9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine 
• 1839-18-5 2-chloroadenine 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 1353040-42-2 2-chloro-9-(3',5'-di-O-benzoyl-β-D-ribofuranosyl)adenine 

Downstream Products

• 355138-50-0 6-amino-2-chloro-9-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purine 
• 1093278-65-9 2-chloro-9-(3',5'-di-O-benzoyl-2'-deoxy-2'-chloro-β-D-arabinofuranosyl)-adenine 
• 123318-82-1 clofarabine 

Relevant articles and documents

METHOD FOR THE SYNTHESIS OF CLOFARABINE

The present invention relates to a method for the high yield production of the anticancer nucleoside clofarabine, the method comprising the preparation of 2-chloroadenosine by enzymatic transglycosylation between 2-chloroadenine and nucleosides, benzoylation, isomerization, sulfonate ester formation, fluorination, and deprotection.

Preparation of 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-adenine

A process for making clofarabine comprising: fluorinating a compound of formula VII wherein each R4 is independently a hydroxy protecting group, OR6 is a leaving group, with a fluorinating agent in the presence of guanidine carbonate to give a compound of formula VIII: wherein R4 is as defined above; and deprotecting the compound of formula VIII to give the clofarabine.