13515-97-4Relevant articles and documents
Synthesis, crystal structure and insecticidal activity of the optical active neonicotinoid analogues
Xue, Sijia,Bu, Hongfei,Liu, Li,Xu, Xiao,Ma, Xubo
, p. 1011 - 1016 (2011)
Eight novel neonicotinoid analogues 1-(2-tetrahydrofurfuryl)-5-substituted- 1,3,5-hexahydrotriazine-2-N-nitroimines 3a - 3h were synthesized, and their structures were characterized by 1H NMR, IR and elemental analysis. The stereostructure of 3a was determined by the single-crystal X-ray analysis, which exhibits a half-chair conformation and dihedral angle is 49.70° . The preliminary bioassay tests showed that all the title compounds exhibited good insecticide activities against Nilaparvata legen (N. legen).
Synthesis and application of peptide borate compounds
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Paragraph 0142-0148, (2019/12/25)
The invention belongs to the field of drug synthesis, and specifically relates to a series of novel peptide borate compounds or pharmaceutical salts thereof, and a preparation method and pharmaceutical application thereof. The structure of the peptide borate compounds or the pharmaceutical salts thereof is as shown in a formula I which is described in the specification. The compounds of the invention can be used for preparing proteasome inhibitors, and thus can be further used for treating solid tumors and blood tumors.
Preparation method of N-alkoxy oxalyl alanine ester
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Paragraph 0036-0037; 0042-0047, (2019/12/02)
The invention discloses a preparation method of N-alkoxy oxalyl alanine ester, which comprises the following steps: (1) under the action of triphosgene and an organic alkali, carrying out an esterification reaction on alanine and an alcohol to obtain alanine ester hydrochloride; and (2) under the action of the organic alkali, carrying out an amidation reaction on the alanine ester hydrochloride obtained in the step (1) and oxalic ester, and after the reaction is finished, carrying out post-treatment to obtain the N-alkoxy oxalyl alanine ester. According to the preparation method, the triphosgene and the organic alkali are used as reaction additives, so that the use of toxic solvent benzene is avoided, the reaction time is shortened, the product purity and the reaction yield are high, and the preparation method is suitable for industrial production.