135040-86-7Relevant articles and documents
Facile preparation of 2-arylbenzo[b]furan molecules and their anti-inflammatory effects
Hwang, Jung Woon,Choi, Da Hye,Jeon, Jae-Ho,Kim, Jin-Kyung,Jun, Jong-Gab
experimental part, p. 965 - 970 (2010/11/02)
An efficient and practical preparation of 2-arylbenzo[b]furan molecules including natural egonol, XH-14, ailanthoidol, and unnatural derivatives is demonstrated using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared benzo[b]furans were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that ailanthoidol, XH-14 and three other unnatural derivatives (9-10, 13) inhibited significantly the production of inflammatory mediator nitric oxide without showing cytotoxicity.
Naturally Occurring Benzofuran: Isolation, Structure Elucidation and Total Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzofurancarbaldehyde, a Novel Adenosine A1 Receptor Ligand Isolated from Salvia miltior
Yang, Zhen,Hon, Po Ming,Chui, Kuk Ying,Xu, Zun Le,Chang, Hson Mou,et al.
, p. 2061 - 2064 (2007/10/02)
A naturally occurring benzofuran, namely 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzofurancarbaldehyde was isolated from the roots of S. miltiorrhiza Bunge "Danshen".Its structure was established by means of spectroscopic metho