134330-11-3

Basic information

• Product Name: 2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)-
• CAS NO: 134330-11-3
• Molecular Formula: C13H15NO
• Molecular Weight: 201.268
• Mol File: 134330-11-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)-(134330-11-3)
• EPA Substance Registry System: 2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)-(134330-11-3)

Safety Data

• Hazardous Substances Data: 134330-11-3(Hazardous Substances Data)

Usage

General Description

2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)- is a chemical compound with the molecular formula C14H17NO. It is commonly known as N-(p-tolyl) acrylamide and is used in various industrial and research applications. 2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)- is a light yellow liquid at room temperature and is insoluble in water, but soluble in organic solvents. It is mainly used as a raw material in the synthesis of pharmaceuticals, agrochemicals, and rubber chemicals. It is also used in the production of polymer resins and coatings. Additionally, 2,4-Hexadienamide, N-(4-methylphenyl)-, (2E,4E)- has shown potential as a pharmaceutical intermediate, with research focusing on its potential antitumor and anti-inflammatory properties.

Upstream product

• 110-44-1 sorbic Acid 
• 106-49-0 p-toluidine 
• 2614-88-2 sorbinyl chloride 

Relevant articles and documents

Quantitative structure-activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivatives

A new series of 2,4-hexadienoic acid derivatives (S1-S42) has been synthesized and evaluated as antimicrobial agents against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger. Quantitative structure-activity relationship (QSAR) investigation using Hansch analysis was applied to find out correlation between antimicrobial activities with physicochemical properties of the synthesized compounds. Various physicochemical descriptors and experimentally determined minimum inhibitory concentration values for different microorganisms were used as independent and dependent variables, respectively. The QSAR revealed that topological parameters especially molecular connectivity indices (χ2, 0χv, 2χv) were found to have overall significant correlation with antimicrobial activity of 2,4-hexadienoic acid derivatives. The statistical results of training set, cross-validated r2 and conventional r values gave reliability to the prediction of molecules with activity using QSAR models.

Synthesis of cyclopentaquinoline system

Reaction of N-aryl-sorbamides (3) with polyphosphoric acid gives cyclopentaquinolines (4) and 4-propyl-carbostyrils (5).