1338823-35-0 Usage
General Description
Lysine(crotonyl)-OH, also known as crotonyl-lysine, is a chemically modified form of the amino acid lysine. This modification involves the addition of a crotonyl group to the lysine molecule, which can affect its function and properties within a biological system. Crotonyl-lysine has been found to be involved in various cellular processes, including gene regulation and protein function. It is also known to play a role in the regulation of histone proteins, which are important for the packaging of DNA within the nucleus. Research on crotonyl-lysine is still ongoing, but it is thought to have potential implications for understanding the epigenetic regulation of gene expression and the development of novel therapies for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1338823-35-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,8,8,2 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1338823-35:
(9*1)+(8*3)+(7*3)+(6*8)+(5*8)+(4*2)+(3*3)+(2*3)+(1*5)=170
170 % 10 = 0
So 1338823-35-0 is a valid CAS Registry Number.
1338823-35-0Relevant articles and documents
Site-specific incorporation of μ-N-crotonyllysine into histones
Kim, Chan Hyuk,Kang, Mingchao,Kim, Hak Joong,Chatterjee, Abhishek,Schultz, Peter G.
, p. 7246 - 7249 (2012)
A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valuable in elucidating the biological role of this recently identified post-translational modification. Copyright
