1338378-17-8

Basic information

• Product Name: 4-chloro-3-ethoxy-1-phenyl-1H-pyrazole
• CAS NO: 1338378-17-8
• Molecular Weight: 222.674
• Mol File: 1338378-17-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-3-ethoxy-1-phenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-3-ethoxy-1-phenyl-1H-pyrazole(1338378-17-8)
• EPA Substance Registry System: 4-chloro-3-ethoxy-1-phenyl-1H-pyrazole(1338378-17-8)

Safety Data

• Hazardous Substances Data: 1338378-17-8(Hazardous Substances Data)

Upstream product

• 1008-79-3 1-phenyl-1H-pyrazol-3-ol 
• 59-88-1 phenylhydrazine hydrochloride 
• 92-43-3 1-phenylpyrazolidin-3-one 
• 1207432-03-8 3-ethoxy-1-phenyl-1H-pyrazole 

Relevant articles and documents

DMF-catalyzed direct and regioselective C-H functionalization: Electrophilic/nucleophilic 4-halogenation of 3-oxypyrazoles

A novel, straightforward, and highly regioselective 4-chlorination of 3-oxypyrazole derivatives in boiling thionyl chloride (SOCl2) in the presence of catalytic N,N-dimethylformamide (DMF) has been developed. This reaction likely proceeds through a DMF-catalyzed electrophilic/nucleophilic chlorination mechanism and involves electrophilic attack by SOCl2 and nucleophilic substitution by Cl- as the key steps. Based on this mechanism, the corresponding 4-bromination and 4-iodination of 3-oxypyrazoles have also been achieved in good yield by adding Br- and I -, respectively, to the reaction system. This halogenation method enables quick access to many original 4-halo-3-oxypyrazole series. A novel DMF-catalyzed electrophilic/nucleophilic 4-halogenation of 3-oxypyrazole derivatives has been developed. This halogenation procedure provides quick access to many novel 4-halo-3-oxypyrazole series.