1338321-15-5

Basic information

• Product Name: C₁₇H₁₅NO₅S
• CAS NO: 1338321-15-5
• Molecular Weight: 345.376
• Mol File: 1338321-15-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₅NO₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₅NO₅S(1338321-15-5)
• EPA Substance Registry System: C₁₇H₁₅NO₅S(1338321-15-5)

Safety Data

• Hazardous Substances Data: 1338321-15-5(Hazardous Substances Data)

Upstream product

• 1196-69-6 1H-indole-5-carboxaldehyde 
• 23095-31-0 3,4-dimethoxybenzene-1-sulfonyl chloride 

Downstream Products

• 1338321-26-8 3-[1-(3,4-dimethoxybenzenesulfonyl)-1H-indol-5-yl]acrylic acid 
• 1338321-19-9 C₂₀H₁₉NO₆S 

Relevant articles and documents

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N -hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo

A series of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles has been identified as a new class of histone deacetylase inhibitors. Compounds 8, 11, 12, 13, and 14 demonstrated stronger antiproliferative activities than 1 (SAHA) with GI50 values ranging from 0.36 to 1.21 μM against Hep3B, MDA-MB-231, PC-3, and A549 human cancer cell lines. Lead compound 8 showed remarkable HDAC 1, 2, and 6 isoenzymes inhibitory activities with IC 50 values of 12.3, 4.0, 1.0 nM, respectively, which are comparable to 1. In in vivo efficacy evaluation against lung A549 xenograft model, 8 displayed better antitumor activity than compound 1.