133525-01-6 Usage
Description
3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT, also known as AZT glucuronide sodium salt, is a metabolite of the potent and selective inhibitor of HIV-1 replication, AZT. It is an off-white solid with unique chemical properties that make it a valuable compound in the field of pharmaceuticals and medicine.
Uses
Used in Pharmaceutical Industry:
3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT is used as an active pharmaceutical ingredient for the development of antiretroviral medications targeting HIV-1 replication. Its role in inhibiting the virus makes it a crucial component in the fight against HIV/AIDS.
Used in Research and Development:
In the research industry, 3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT serves as a valuable tool for studying the mechanisms of HIV-1 replication and the effectiveness of antiretroviral therapies. It aids scientists in understanding the drug's metabolism and potential side effects, thereby contributing to the improvement of HIV treatment strategies.
Used in Quality Control and Standardization:
3'-AZIDO-3'-DEOXYTHYMIDINE BETA-D-GLUCURONIDE, SODIUM SALT is utilized in the quality control processes of pharmaceutical manufacturing. It helps ensure the standardization and consistency of antiretroviral drug products, guaranteeing their safety and efficacy for patients.
Biological Activity
3'-azido-3'-deoxythymidine β-d-glucuronide is the metabolite of zidovudine, a nucleoside reverse transcriptase inhibitor.zidovudine, an antiretroviral medication used to prevent and treat hiv, is recommended for use with other antiretroviral and may be also used to prevent mother to child spread during birth or after a needlestick injury or other potential exposure.
in vitro
3'-azido-3'-deoxythymidine β-d-glucuronide is a metabolite of zidovudine, formed by direct conjugation by udp-glucuronosyltransferase 2b7. the azido group of both zidovudine and 3'-azido-3'-deoxythymidine β-d-glucuronide could be reduced to an amino group by cytochrome cyp3a, cyp2a6, or cyp2b1, forming 3’-amino-3’-deoxythymidine (amt) and amt glucuronide, respectively [1].
in vivo
animal study found that zidovudine-treated rats had higher systolic blood pressure, greater heart weight and greater interventricular septum thickness. electron microscopy revealed mitochondrial swelling in myocardiocytes in zidovudine-treated rats. reduced response to contractile stimuli and enhanced relaxation in response to charbacol were observed in the aortic rings of zidovudine-treated rats. the aortic myocytes of zidovudine-treated rats contained apparently unaffected ultrastructural features, but light microscopy suggested their marked enlargement [2].
references
[1] walsky, r. l.,bauman, j.n.,bourcier, k., et al. optimized assays for human udp-glucuronosyltransferase (ugt) activities: altered alamethicin concentration and utility to screen for ugt inhibitors. drug metabolism and disposition 40(5), 1051-1065 (2012).[2] ruga e, bova s, nussdorfer g, mazzocchi g, rebuffat p, milanesi o, cargnelli g. zidovudine-induced alterations in the heart and vascular smooth muscle of the rat. cardiovasc res. 2003 oct 15;60(1):147-55.
Check Digit Verification of cas no
The CAS Registry Mumber 133525-01-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,5,2 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133525-01:
(8*1)+(7*3)+(6*3)+(5*5)+(4*2)+(3*5)+(2*0)+(1*1)=96
96 % 10 = 6
So 133525-01-6 is a valid CAS Registry Number.
