1333326-62-7Relevant articles and documents
Rhodium-catalyzed domino enantioselective synthesis of bicyclo[2.2.2] lactones
Boyer, Alistair,Lautens, Mark
, p. 7346 - 7349 (2011/09/16)
Once, twice, three times a catalyst! A novel domino rhodium(I)-catalyzed asymmetric transformation of substituted oxabicyclic alkenes into bicyclo[2.2.2]lactones proceeded with good yields (up to 78 %) and excellent stereoselectivity (>97 % ee; see scheme; cod=1,5-cyclooctadiene, Tf=trifluoromethanesulfonyl). Mechanistic investigations suggest that this process proceeds by rhodium-catalyzed asymmetric ring opening, allylic alcohol isomerization and oxidation. Copyright