1333326-61-6

Basic information

• Product Name: (1R,3R,4R)-4-hydroxymethyl-3-((S)-N-methyl-alpha-methylbenzylamino)-1,2,3,4-tetrahydronaphthalen-1,4-olide
• Synonyms: (1R,3R,4R)-4-hydroxymethyl-3-((S)-N-methyl-alpha-methylbenzylamino)-1,2,3,4-tetrahydronaphthalen-1,4-olide
• CAS NO: 1333326-61-6
• Molecular Weight: 337.419
• Mol File: 1333326-61-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,3R,4R)-4-hydroxymethyl-3-((S)-N-methyl-alpha-methylbenzylamino)-1,2,3,4-tetrahydronaphthalen-1,4-olide(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R,4R)-4-hydroxymethyl-3-((S)-N-methyl-alpha-methylbenzylamino)-1,2,3,4-tetrahydronaphthalen-1,4-olide(1333326-61-6)
• EPA Substance Registry System: (1R,3R,4R)-4-hydroxymethyl-3-((S)-N-methyl-alpha-methylbenzylamino)-1,2,3,4-tetrahydronaphthalen-1,4-olide(1333326-61-6)

Safety Data

• Hazardous Substances Data: 1333326-61-6(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 19131-99-8 N-methyl-N-[(S)-1-phenylethyl]amine 
• 1883-75-6 2,5-bis-(hydroxymethyl)furan 
• 98-00-0 (2-furyl)methyl alcohol 

Relevant articles and documents

Rhodium-catalyzed domino enantioselective synthesis of bicyclo[2.2.2] lactones

Once, twice, three times a catalyst! A novel domino rhodium(I)-catalyzed asymmetric transformation of substituted oxabicyclic alkenes into bicyclo[2.2.2]lactones proceeded with good yields (up to 78 %) and excellent stereoselectivity (>97 % ee; see scheme; cod=1,5-cyclooctadiene, Tf=trifluoromethanesulfonyl). Mechanistic investigations suggest that this process proceeds by rhodium-catalyzed asymmetric ring opening, allylic alcohol isomerization and oxidation. Copyright