133059-43-5

Basic information

• Product Name: 4-Bromo-3-fluorobenzaldehyde
• Synonyms: 4-BROMO-3-FLUOROBENZALDEHYDE;4-Bromo-3-fluorobenzaldehyde 98%;4-Bromo-3-fluorobenzaldehyde98%;3-Fluoro-4-bromobenzaldehyde;Benzaldehyde, 4-broMo-3-fluoro-;4-BroMo-3-fluorobenzaldehyde, 95+%;4 - broMine - 3 - fluoro benzaldehyde
• CAS NO: 133059-43-5
• Molecular Formula: C₇H₄BrFO
• Molecular Weight: 203.01
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Miscellaneous;Aldehydes;Aryl Fluorinated Building Blocks;Building Blocks;C7;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 133059-43-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 55-59℃
• Boiling Point: 240.2 °C at 760 mmHg
• Flash Point: 99.1 °C
• Appearance: /
• Density: 1.67 g/cm³
• Vapor Pressure: 0.0384mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-Bromo-3-fluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-fluorobenzaldehyde(133059-43-5)
• EPA Substance Registry System: 4-Bromo-3-fluorobenzaldehyde(133059-43-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 133059-43-5(Hazardous Substances Data)

Usage

Description

4-Bromo-3-fluorobenzaldehyde is an organic compound characterized by its white powder form. It is a derivative of benzaldehyde with a bromine atom at the 4th position and a fluorine atom at the 3rd position on the benzene ring. 4-Bromo-3-fluorobenzaldehyde is known for its distinct chemical properties, which make it a valuable intermediate in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
4-Bromo-3-fluorobenzaldehyde is used as a key intermediate in the synthesis of Deuterated Dihydropyrimidine compounds. These compounds have demonstrated potential as anti-HBV (Hepatitis B Virus) agents, making 4-Bromo-3-fluorobenzaldehyde an essential component in the development of novel treatments for Hepatitis B.
The specific application of 4-Bromo-3-fluorobenzaldehyde in the pharmaceutical industry is due to its ability to be incorporated into the molecular structure of Deuterated Dihydropyrimidine compounds, which have shown promise in combating the Hepatitis B Virus. This makes it a valuable asset in the ongoing efforts to develop effective treatments for this viral infection.

InChI:InChI=1/C7H4BrFO/c8-6-2-1-5(4-10)3-7(6)9/h1-4H

Upstream product

• 127425-73-4 1-bromo-4-(bromomethyl)-2-fluorobenzene 
• 133059-44-6 4-bromo-3-fluorobenzonitrile 
• 350587-20-1 1-bromo-4-(dibromomethyl)-2-fluorobenzene 
• 201230-82-2 carbon monoxide 
• 136434-77-0 4-bromo-3-fluoroiodobenzene 
• 124-38-9 carbon dioxide 
• 222978-01-0 4-bromo-3-fluorobenzyl alcohol 

Downstream Products

• 950691-70-0 1-bromo-4-(diethoxymethyl)-2-fluorobenzene 
• 950691-66-4 methyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate 
• 1427405-76-2 4-bromo-5-fluoro-2-hydroxybenzaldehyde 

Related news

Analysis of 4-Bromo-3-fluorobenzaldehyde (cas 133059-43-5) and separation of its regioisomers by one-dimensional and two-dimensional gas chromatography09/02/2019

A starting material, 4-bromo-3-fluorobenzaldehyde, was used for active drug substance (API) AMG 369 production. The presence of the regioisomer impurities in the starting material 4-bromo-3-fluorobenzaldehyde presented significant challenges for the API synthetic route development due to the phy...detailed

Relevant articles and documents

Rhodium-catalyzed reductive carbonylation of aryl iodides to arylaldehydes with syngas

The reductive carbonylation of aryl iodides to aryl aldehydes possesses broad application prospects. We present an efficient and facile Rh-based catalytic system composed of the commercially available Rh salt RhCl3·3H2O, PPh3 as phosphine ligand, and Et3N as the base, for the synthesis of arylaldehydes via the reductive carbonylation of aryl iodides with CO and H2 under relatively mild conditions with a broad substrate range affording the products in good to excellent yields. Systematic investigations were carried out to study the experimental parameters. We explored the optimal ratio of Rh salt and PPh3 ligand, substrate scope, carbonyl source and hydrogen source, and the reaction mechanism. Particularly, a scaled-up experiment indicated that the catalytic method could find valuable applications in industrial productions. The low gas pressure, cheap ligand and low metal dosage could significantly improve the practicability in both chemical researches and industrial applications.

ORTHO AMINOAMIDES FOR THE TREATMENT OF CANCER

Compounds of formula are HDAC inhibitors. These compounds are useful for the treatment of diseases such as cancer in humans or animals.

REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B

The instant invention relates to compounds of formula I, diagrammed below, wherein R3, E, D and Y are defined in the application, which are useful as reversible inhibitors of monoamine oxidase-B and/or monoamine oxidase-A, and therefore useful to treat or prevent neurological diseases or conditions in mammals, preferably humans.