1304788-26-8 Usage
Description
(4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione is a complex organic compound with a unique molecular structure. It is characterized by its acetyloxy and hydroxy functional groups, which contribute to its chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
(4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione is used as an intermediate in the synthesis of Camptothecin analogs. These analogs are known for their ability to inhibit topoisomerase I, an enzyme that plays a crucial role in DNA replication. By targeting this enzyme, Camptothecin analogs can exhibit antitumor activity, making them valuable in the development of cancer treatments.
Used in Cancer Research:
In the field of cancer research, (4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione serves as a key component in the development of novel therapeutic strategies. Its role in the synthesis of Camptothecin analogs allows researchers to explore new avenues for cancer treatment, potentially leading to more effective and targeted therapies for various types of cancer.
Used in Drug Development:
(4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione is also utilized in drug development, particularly in the creation of new compounds with potential antitumor properties. Its unique structure and functional groups make it an attractive candidate for further modification and optimization, potentially leading to the discovery of more potent and selective inhibitors of topoisomerase I.
Check Digit Verification of cas no
The CAS Registry Mumber 1304788-26-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,4,7,8 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1304788-26:
(9*1)+(8*3)+(7*0)+(6*4)+(5*7)+(4*8)+(3*8)+(2*2)+(1*6)=158
158 % 10 = 8
So 1304788-26-8 is a valid CAS Registry Number.
1304788-26-8Relevant articles and documents
The solvolysis of topotecan in alcohols and acetic anhydride
Li, Jiajun,Wang, Guolin,Dong, Mengjie,Zhang, Qian
, p. 2324 - 2326 (2011)
Six derivatives of 10-hydroxycamptothecin were prepared via solvolysis of topotecan in corresponding alcohols and acetic anhydride. We attributed the specific reactivity of topotecan to the internal hydrogen-bonding between 10-hydroxy and the nitrogen atom in position 9. As a result the reaction underwent through an intermediate ortho-quionomethlide species to reach equilibrium. Bioactivity screening data showed all products could potentially inhibit the proliferation of several cancer cell lines in vitro and a bigger size group in 9-position would be favorable for the anti-tumor activities observably.
