1303607-60-4 Usage
Description
SAR405838 (MI-773) is a potent inhibitor of the MDM2-p53 protein-protein interaction, specifically targeting the MDM2 protein to restore the function of the tumor suppressor p53 in cancer cells.
Uses
Used in Pharmaceutical Industry:
SAR405838 (MI-773) is used as an anticancer agent for the treatment of various types of cancer. It works by inhibiting the MDM2 protein, which in turn activates the wild-type p53 protein, leading to p53-dependent cell cycle arrest and/or apoptosis in cancer cells.
Used in Clinical Trials:
SAR405838 (MI-773) is used as a candidate drug in clinical trials for cancer treatment. It has shown promising results in inducing tumor regression in xenograft models of leukemia and solid tumors, such as osteosarcoma, by upregulating the pro-apoptotic protein PUMA.
references
[1]. wang s, sun w, zhao y, et al. sar405838: an optimized inhibitor of mdm2-p53 interaction that induces complete and durable tumor regression. cancer res, 2014, 74(20): 5855-5865.
Check Digit Verification of cas no
The CAS Registry Mumber 1303607-60-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,3,6,0 and 7 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1303607-60:
(9*1)+(8*3)+(7*0)+(6*3)+(5*6)+(4*0)+(3*7)+(2*6)+(1*0)=114
114 % 10 = 4
So 1303607-60-4 is a valid CAS Registry Number.
