129468-49-1

Basic information

• Product Name: Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside
• Synonyms: Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside
• CAS NO: 129468-49-1
• Molecular Weight: 328.365
• Mol File: 129468-49-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside(129468-49-1)
• EPA Substance Registry System: Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside(129468-49-1)

Safety Data

• Hazardous Substances Data: 129468-49-1(Hazardous Substances Data)

Upstream product

• 125611-95-2 methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside 
• 129468-48-0 Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-glyceropentofuranosid-3-ulose 

Downstream Products

• 129468-51-5 methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside 
• 129468-52-6 1-<2,3-Dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-α/β-D-erythro-pentofuranosy>-5-methyl-2,4(1H,3H)-pyrimidinedione 
• 25526-93-6 alovudine 
• 129468-51-5 Methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside 

Relevant articles and documents

Synthesis of hydantoin analogues of 3'-fluoro-3'-deoxythymidine (FLT)

Reaction of methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside 2 with diethylaminosulfur trifluoride (DAST) in a 1:10 molar ratio in CH2Cl2 at room temperature for 5 d afforded methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentafuranoside 4 in 57percent yield, while the α-anomer 3 under the same reaction conditions yielded the 3-fluoro-α-D-erythro derivative 10 in 14percent yield together with the 5-fluoro-D-α--threo derivative 11 in 22percent yield. (Z)-5-Benzylidene-, (E)-ethylidene- and 5,5-dimethylhydantoin nucleosides were obtained by condensation of the appropriate silylated nucleobases with 4.The protected nucleosides were in all cases deblocked by treatment with sodium methoxide in methanol.The (Z)-ethylidene group isomerized to the E configuration during the nucleoside synthesis. - Key words: hydantoin / 3'-fluoro-3'-deoxythymidine / methyl 2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranoside