129098-58-4 Usage
Description
(R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE is a chemical compound characterized by its molecular formula C10H11ClO2. It is an epoxide, featuring a three-membered ring composed of one oxygen atom and two carbon atoms. (R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE is distinguished by the presence of a chlorine atom attached to a phenyl group, which is connected to a methylene group that forms part of the epoxide ring. Due to its unique structure, it may find applications in organic synthesis and could serve as a starting material for the production of other chemical compounds. However, it is crucial to handle this compound with caution, as epoxides are known to be hazardous if not managed properly.
Uses
Used in Organic Synthesis:
(R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE is used as a key intermediate in organic synthesis for the creation of various chemical compounds. Its unique structure allows for versatile reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used as a Starting Material:
In the chemical industry, (R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE is utilized as a starting material for the production of other chemical compounds. Its epoxide functionality and the presence of a chlorine atom on the phenyl group provide opportunities for further chemical modifications, leading to the development of new molecules with specific properties and applications.
Used in Pharmaceutical Industry:
(R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE is used as a building block in the pharmaceutical industry for the development of new drugs. Its unique structure can be exploited to create molecules with specific biological activities, potentially leading to the discovery of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE is employed as a precursor for the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties can be tailored to create compounds with targeted effects on pests and weeds, contributing to more effective and sustainable agricultural practices.
Used in Specialty Chemicals:
(R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE is also used in the production of specialty chemicals, which are high-value compounds with specific applications in various industries. Its unique structure and reactivity make it suitable for the development of advanced materials, such as polymers, coatings, and adhesives.
Check Digit Verification of cas no
The CAS Registry Mumber 129098-58-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,0,9 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 129098-58:
(8*1)+(7*2)+(6*9)+(5*0)+(4*9)+(3*8)+(2*5)+(1*8)=154
154 % 10 = 4
So 129098-58-4 is a valid CAS Registry Number.
129098-58-4Relevant articles and documents
Chiral Bifunctional Metalloporphyrin Catalysts for Kinetic Resolution of Epoxides with Carbon Dioxide
Maeda, Chihiro,Mitsuzane, Mayato,Ema, Tadashi
supporting information, p. 1853 - 1856 (2019/03/11)
Chiral binaphthyl-strapped Zn(II) porphyrins with triazolium halide units were synthesized as bifunctional catalysts for kinetic resolution of epoxides with CO2. Several catalysts were screened by changing the linker length and nucleophilic counteranions, and the optimized catalyst accelerated the enantioselective reaction at ambient temperature to produce optically active cyclic carbonates and epoxides.
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl) piperazine derivatives as T-type calcium channel blockers
Park, Jung-Eun,Ji, Wan Keun,Jang, Jae Wan,Pae, Ae Nim,Choi, Keehyun,Choi, Ki Hang,Kang, Jahyo,Roh, Eun Joo
supporting information, p. 1887 - 1890 (2013/04/10)
To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and 6q showed high selectivity over hERG
Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antiseptics
Chavez, Sherry A.,Martinko, Alexander J.,Lau, Corinna,Pham, Michael N.,Cheng, Kui,Bevan, Douglas E.,Mollnes, Tom E.,Yin, Hang
, p. 4659 - 4669 (2011/09/15)
Toll-like receptor 4 (TLR4) induced proinflammatory signaling has been directly implicated in severe sepsis and represents an attractive therapeutic target. Herein, we report our investigations into the structure-activity relationship and preliminary drug metabolism/pharmacokinetics study of β-amino alcohol derivatives that inhibit the TLR4 signaling pathway. Lead compounds were identified from in vitro cellular examination with micromolar potency for their inhibitory effects on TLR4 signaling and subsequently assessed for their ability to suppress the TLR4-induced inflammatory response in an ex vivo whole blood model. In addition, the toxicology, specificity, solubility, brain-blood barrier permeability, and drug metabolism of several compounds were evaluated. Although further optimizations are needed, our findings lay the groundwork for the future drug development of this class of small molecule agents for the treatment of severe sepsis.
