128446-36-6

Basic information

• Product Name: beta-Cyclodextrin methyl ethers
• Synonyms: .beta.-cyclodextrin,methylethers;METHYL-BETA-CYCLODEXTRIN;MBC;BETA-W7 M1.8;BETA-CYD;Dimethyl-β-Cyclodextrin;Methyl-?cyclodextrin;methyl-B-cyclodextrin cell culture*tested
• CAS NO: 128446-36-6
• Molecular Formula: C54H94O35
• Molecular Weight: 1303.3
• EINECS: 1308068-626-2
• Product Categories: Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Dextrins、Sugar & Carbohydrates;Carbohydrates;Carbohydrates A to;Carbohydrates M-OSynthetic Reagents;CyclodextrinsBiochemicals and Reagents;Polysaccharide;Chelation/Complexation Compounds;Synthetic Reagents;Cell Signaling and Neuroscience;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Lipids and Lipid Carriers;Reagents and Supplements;Signal Transduction Research Tools
• Mol File: 128446-36-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 180-182 °C(lit.)
• Boiling Point: 1206.9±65.0 °C at 760 mmHg
• Flash Point: 187 °C
• Appearance: White to off-white/powder
• Density: 1.4 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: room temp
• Solubility: H2O: soluble50mg/mL
• Water Solubility: Soluble in water
• CAS DataBase Reference: beta-Cyclodextrin methyl ethers(CAS DataBase Reference)
• NIST Chemistry Reference: beta-Cyclodextrin methyl ethers(128446-36-6)
• EPA Substance Registry System: beta-Cyclodextrin methyl ethers(128446-36-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 128446-36-6(Hazardous Substances Data)

Usage

Description

Beta-Cyclodextrin methyl ethers, also known as Methyl-β-cyclodextrin, is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin. It is a small cyclic heptasaccharide containing seven D-(+)-glucopyranose units with randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. It is also known for its ability to reduce α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein, as well as in mouse brain in a transgenic model of α-synucleinopathy. Methyl-β-cyclodextrin is presented as a white powder.

Uses

1. Used as a substrate for laminarinase and other glucanases.
2. Used in Tissue and Cell Culture Applications:
Beta-Cyclodextrin methyl ethers is used as a complexing agent for increasing the solubility of non-polar substances such as fatty acids, lipids, vitamins, and cholesterol.
3. Used in Cholesterol Removal:
Methyl-β-cyclodextrin is used as a cholesterol-removing agent, mainly for lipid raft disruption.
4. Used in Detergent Removal:
Methyl-β-cyclodextrin is used as a detergent removal agent from protein-lipid-detergent ternary mixtures to produce 2D membrane protein crystals, due to its high solubility and affinity for detergents generally used in membrane protein chemistry.

Biochem/physiol Actions

Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.

InChI:InChI=1/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3