128231-13-0

Basic information

• Product Name: 5-(3,6-Dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3-[4-(1,1-dimethylethyl) phenylhydrazone]
• Synonyms: 5-(3,6-Dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3-[4-(1,1-dimethylethyl) phenylhydrazone]
• CAS NO: 128231-13-0
• Molecular Weight: 421.523
• Mol File: 128231-13-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3,6-Dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3-[4-(1,1-dimethylethyl) phenylhydrazone](CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,6-Dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3-[4-(1,1-dimethylethyl) phenylhydrazone](128231-13-0)
• EPA Substance Registry System: 5-(3,6-Dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3-[4-(1,1-dimethylethyl) phenylhydrazone](128231-13-0)

Safety Data

• Hazardous Substances Data: 128231-13-0(Hazardous Substances Data)

Upstream product

• 36600-66-5 4-tert-butylphenylhydrazine hydrochloride 
• 128230-98-8 1,3-dihydro-5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-3-phenylimino-2H-indol-2-one 

Relevant articles and documents

Indolythiadiazines for treating heart failure

A compound of formula (I) or a pharmaceutically acceptable salt thereof, STR1 in which, R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; R4 and R4 ' together form a group =N--Ra, or =CRaRb, where Ra is hydrogen, lower alkyl, aryl, aryloxy, lower alkylcarbonyl, arylcarbonyl, aryloxycarbonyl, lower alkoxy, lower alkoxy carbonyl, lower alkoxy carbonyl alkoxy, lower thioalkoxy, hydroxy, nitrile, heterocyclyl, or --NRcRd, where Rc is hydrogen, lower alkyl, cycloalkyl, aryl, aralkyl, lower alkylcarbonyl, arylcarbonyl, aminocarbonyl, aminothiocarbonyl, aminoiminocarbonyl, lower alkoxycarbonyl, lower alkoxythiocarbonyl, aryloxycarbonyl, thiocarbonyl, nitrile, carboxyl, heterocyclyl or heterocyclylcarbonyl, and Rd is hydrogen or lower alkyl; Rb is hydrogen, lower alkyl, aryl, lower alkylcarbonyl, lower alkoxycarbonyl, nitrile or nitro; or R4 is --NH--Ra, in which Ra is as defined above, and R4 ' is hydrogen or lower alkyl; each of R3 and R5 is independently hydrogen, lower alkyl, aryl, lower alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclylcarbonyl, optionally substituted aminocarbonyl, lower alkoxycarbonyl or aryloxycarbonyl; R6 is hydrogen, lower alkyl or halogen; and A is sulphur, oxygen, --NH-- or --CH2 --, is useful for the treatment of heart disease.