128-57-4 Usage
Description
Sennoside B, a member of the sennoside class, is a white to brown powder with the chemical formula (9R,9'S)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid. It is characterized by hydroxy groups at positions 4 and 4', beta-D-glucopyranosyloxy groups at positions 5 and 5', and oxo groups at positions 10 and 10'. Sennoside B is known for its potential inhibitory effects on platelet-driven growth factor (PDGF) and its use as a laxative.
Uses
Used in Pharmaceutical Industry:
Sennoside B is used as an inhibitor of platelet-driven growth factor (PDGF) for its potential to inhibit proliferative diseases that depend on the PDGF pathway. This makes it a promising candidate for the development of treatments targeting various conditions related to PDGF.
Used as a Laxative:
Sennoside B is also used as a laxative, helping to relieve constipation and promote bowel movements. Its effectiveness in this application is attributed to its ability to stimulate the intestinal tract and increase peristalsis.
Purification Methods
Sennoside B forms yellow crystals from aqueous acetone or large volumes of H2O. [Stoll et al. Helv Chim Acta 32 1896 1900, Beilstein 17 III/IV 3402.]
Check Digit Verification of cas no
The CAS Registry Mumber 128-57-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 128-57:
(5*1)+(4*2)+(3*8)+(2*5)+(1*7)=54
54 % 10 = 4
So 128-57-4 is a valid CAS Registry Number.
InChI:InChI=1/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26+,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1