127956-25-6

Basic information

• Product Name: 6-(bromomethyl)-1-(tert-butoxycarbonyl)indole
• Synonyms: 6-(bromomethyl)-1-(tert-butoxycarbonyl)indole
• CAS NO: 127956-25-6
• Molecular Weight: 310.191
• Mol File: 127956-25-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-(bromomethyl)-1-(tert-butoxycarbonyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(bromomethyl)-1-(tert-butoxycarbonyl)indole(127956-25-6)
• EPA Substance Registry System: 6-(bromomethyl)-1-(tert-butoxycarbonyl)indole(127956-25-6)

Safety Data

• Hazardous Substances Data: 127956-25-6(Hazardous Substances Data)

Upstream product

• 127956-24-5 tert-butyl 6-methyl-1H-indole-1-carboxylate 
• 34619-03-9 tert-butyldicarbonate 
• 1196-70-9 indole-6-carboxaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 354587-72-7 tert-butyl 6-(hydroxymethyl)-1H-indole-1-carboxylate 
• 127956-28-9 1-(tert-butoxycarbonyl)-1H-indole-6-carboxaldehyde 
• 3420-02-8 6-methylindole 

Downstream Products

• 127956-28-9 1-(tert-butoxycarbonyl)-1H-indole-6-carboxaldehyde 
• 1196-70-9 indole-6-carboxaldehyde 
• 127956-27-8 6-(difluoromethyl)indole 

Relevant articles and documents

Copper-catalyzed sp3-sp3 cross-coupling of turbo grignards with benzyl halides

The aromatic ring in benzyl halides and sulfonates imparts unique reactivity at the benzylic carbon atom. Photoredox sp3-sp3 cross-coupling proved ineffective for coupling p-methoxybenzyl chloride (PMBCl), leading to a new strategy for the sp3-sp3 cross-coupling of benzyl halides and sulfonates. This strategy involved LiCl-accelerated synthesis of a Grignard reagent followed by a copper-catalyzed cross-coupling. The conditions worked well for PMBCl due to its exceptional reactivity but other benzyl bromides or sulfonates reacted poorly.