1271738-74-9 Usage
Description
Febuxostat Impurity 6, also known as 2-[3-[(Hydroxyimino)methyl]-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylic Acid Ethyl Ester, is an impurity found in Febuxostat (F229000), a medication used for the treatment of hyperuricemia and chronic gout. It is an Xanthine oxidase/xanthine dehydrogenase inhibitor, which helps in lowering serum urate levels.
Uses
Used in Pharmaceutical Industry:
Febuxostat Impurity 6 is used as a pharmaceutical impurity for the development and manufacturing of Febuxostat, a medication used for the treatment of hyperuricemia and chronic gout. It plays a crucial role in ensuring the quality, safety, and efficacy of the final drug product.
Used in Hyperuricemia Treatment:
Febuxostat Impurity 6 is used as a component in the development of Febuxostat, which is effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout. The recommended dosage for Febuxostat ranges from 40-120 mg/day.
Used in Chronic Gout Management:
Febuxostat Impurity 6 contributes to the development of Febuxostat, a medication that is used for the management of chronic gout. By lowering serum urate levels, it helps in reducing the frequency and severity of gout attacks, improving the overall quality of life for patients suffering from this condition.
Check Digit Verification of cas no
The CAS Registry Mumber 1271738-74-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,7,1,7,3 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1271738-74:
(9*1)+(8*2)+(7*7)+(6*1)+(5*7)+(4*3)+(3*8)+(2*7)+(1*4)=169
169 % 10 = 9
So 1271738-74-9 is a valid CAS Registry Number.
1271738-74-9Relevant articles and documents
Improved method for synthesizing febuxostat key intermediate
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Paragraph 0020-0021; 0024-0025, (2021/01/15)
The invention relates to an improved cyanation reaction method for synthesizing febuxostat. According to the method, the feeding ratio of a compound II to hydroxylamine hydrochloride to sodium formateis 1:1.3:1.3, the amount of formic acid is 8-15 times by volume, the reaction temperature is 90-130 DEG C, the reaction time is 4-10 hours, after the reaction is finished, the temperature is reducedto 40-80 DEG C, an aftertreatment solvent is dropwise added into reaction liquid, after dropwise adding is finished, the temperature is reduced to 10-35 DEG C, fand iltering and drying are performed,so that an intermediate compound (III) with less than 0.10% of related substances.
PROCESSES FOR PREPARING FEBUXOSTAT
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Page/Page column 18, (2011/04/18)
Febuxostat can be prepared from the compound of the following formula (VI); Formula (VI) has been prepared in a one-pot process by combining a compound of the following formula (II); with an organic solvent, isobutyl halide and an inorganic base, to obtain a compound of the following formula (III); Formula III is optionally filtered before combining it with hydroxylamine base or hydroxylamine HCl. A water scavenger is added to obtain the compound of formula VI. Febuxostat can then be prepared, for example, by combining the compound of formula VI with one organic solvent and an alkali metal hydroxide.
