1268140-15-3 Usage
Description
5,7,3'-trihydroxy-4'-methoxy-8-prenylflavanone, also known as a trihydroxyflavanone, is a compound derived from hesperetin and is substituted by a prenyl group at position 8. It is isolated from Macaranga conifera and has been found to exhibit inhibitory activity against breast cancer resistance protein.
Uses
Used in Pharmaceutical Industry:
5,7,3'-trihydroxy-4'-methoxy-8-prenylflavanone is used as a pharmaceutical compound for its inhibitory activity against breast cancer resistance protein. This property makes it a potential candidate for the development of new treatments and therapies for breast cancer and other related conditions.
Used in Cancer Research:
In the field of cancer research, 5,7,3'-trihydroxy-4'-methoxy-8-prenylflavanone is used as a subject of study to better understand its potential effects on cancer cells and resistance mechanisms. This research could lead to the discovery of new therapeutic approaches and the development of more effective cancer treatments.
Used in Drug Development:
5,7,3'-trihydroxy-4'-methoxy-8-prenylflavanone is used as a starting point for the development of new drugs targeting cancer resistance proteins. Its unique structure and properties make it an interesting candidate for further investigation and potential modification to enhance its efficacy and specificity in treating cancer.
Used in Natural Product Chemistry:
In the field of natural product chemistry, 5,7,3'-trihydroxy-4'-methoxy-8-prenylflavanone is used as a representative example of the diverse range of bioactive compounds found in plants. Its isolation and characterization contribute to the understanding of the chemical diversity and potential therapeutic applications of natural products.
Used in Toxicology Studies:
5,7,3'-trihydroxy-4'-methoxy-8-prenylflavanone is used in toxicology studies to evaluate its safety and potential side effects. This information is crucial for determining its suitability as a pharmaceutical compound and for establishing appropriate dosages and administration methods.
Check Digit Verification of cas no
The CAS Registry Mumber 1268140-15-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,8,1,4 and 0 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1268140-15:
(9*1)+(8*2)+(7*6)+(6*8)+(5*1)+(4*4)+(3*0)+(2*1)+(1*5)=143
143 % 10 = 3
So 1268140-15-3 is a valid CAS Registry Number.
1268140-15-3Relevant articles and documents
Regio- and stereospecific prenylation of flavonoids by Sophora flavescens prenyltransferase
Chen, Ridao,Liu, Xiao,Zou, Jianhua,Yin, Yunze,Ou, Bin,Li, Jianhua,Wang, Ruishan,Xie, Dan,Zhang, Peicheng,Dai, Jungui
, p. 1817 - 1828 (2013/07/19)
Prenylflavonoids are valuable natural products that are widely distributed in plants. They often possess divergent biological properties, including phytoestrogenic, anti-bacterial, anti-tumor, and anti-diabetic activities. The reaction catalyzed by prenyltransferases represents a Friedel-Crafts alkylation of the flavonoid skeleton in the biosynthesis of natural prenylflavonoids and often contributes to the structural diversity and biological activity of these compounds. However, only a few plant flavonoid prenyltransferases have been identified thus far, and these prenyltransferases exhibit strict substrate specificity and low catalytic efficiency. In this article, a flavonoid prenyltransferase from Sophora flavescens, SfFPT, has been identified that displays high catalytic efficiency with high regiospecificity acting on C-8 of structurally different types of flavonoid (i.e., flavanone, flavone, flavanonol, and dihydrochalcone, etc.). Furthermore, SfPFT exhibits strict stereospecificity for levorotatory flavanones to produce (2S)-prenylflavanones. This study is the first to demonstrate the substrate promiscuity and stereospecificity of a plant flavonoid prenyltransferase in vitro. Given its substrate promiscuity and high catalytic efficiency, SfFPT can be used as an environmentally friendly and efficient biological catalyst for the regio- and stereospecific prenylation of flavonoids to produce bioactive compounds for potential therapeutic applications. Copyright
