125711-60-6

Basic information

• Product Name: 2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine
• Synonyms: 2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine
• CAS NO: 125711-60-6
• Molecular Weight: 434.879
• Mol File: 125711-60-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine(125711-60-6)
• EPA Substance Registry System: 2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine(125711-60-6)

Safety Data

• Hazardous Substances Data: 125711-60-6(Hazardous Substances Data)

Upstream product

• 103069-48-3 2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-3-(2-cyanoethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 103069-47-2 2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate 
• 141-52-6 sodium ethanolate 
• 103094-34-4 (+)-2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-(methoxycarbonyl)-3-<(2(S)-methoxy-2-phenethoxy)carbonyl>-6-methyl-1,4-dihydropyridine 
• 64-17-5 ethanol 

Downstream Products

• 143191-86-0 (-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine 
• 103129-82-4 amlodipine 

Relevant articles and documents

Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: A correction

The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2- phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.