1256261-45-6Relevant articles and documents
Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives
Chen, Dong,Zhai, Xin,Yuan, Qiu Hui,Luo, Jian,Xie, Si Chang,Gong, Ping
, p. 1326 - 1329 (2011/10/09)
A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100μmol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg.