1251905-45-9 Usage
Description
Methyl (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique chemical structure, which includes a phenyl group attached to an isoquinoline ring, with a carboxylate group attached to the methyl group. methyl (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate plays a significant role in the development of medications for specific medical conditions.
Uses
Used in Pharmaceutical Industry:
Methyl (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate is used as a key intermediate in the asymmetric synthesis method of solifenacin, a drug used for the treatment of overactive bladder. Its unique structure allows for the selective synthesis of solifenacin, which is effective in managing urinary frequency, urgency, and incontinence associated with overactive bladder.
As a precursor in the synthesis of solifenacin succinate, methyl (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate contributes to the development of medications that can significantly improve the quality of life for patients suffering from overactive bladder. Its role in the pharmaceutical industry is essential, as it enables the production of effective treatments for this common medical condition.
Check Digit Verification of cas no
The CAS Registry Mumber 1251905-45-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,1,9,0 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1251905-45:
(9*1)+(8*2)+(7*5)+(6*1)+(5*9)+(4*0)+(3*5)+(2*4)+(1*5)=139
139 % 10 = 9
So 1251905-45-9 is a valid CAS Registry Number.
1251905-45-9Relevant articles and documents
Isoquinoline-N-Boranes as Precursors to Substituted Tetrahydroisoquinolines
Brooks, Donald J.,Dowell, David S.,Minter, David E.,Villarreal, Mark C.
, p. 130 - 133 (1984)
A new approach to the syntheses of 1,2-disubstituted 1,2,3,4-tetrahydroisoquinolines from isoquinoline-N-boranes is described.The method is a "one-pot" operation in which substituents are introduced consecutively as electrophiles and nucleophiles with accompanying reduction of the heterocyclic ring.This procedure differs from the classical ones in that both requisite rings are present in the starting material and thus avoids the inefficient cyclizations of phenethylamine derivatives when unactivated substrates would be required.The synthetic utility of this process is demonstrated with several examples including the alkaloids carnegine and hydrohydrastinine.
Asymmetric synthesis method for preparation of solifenacin
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, (2018/07/10)
The invention relates to an asymmetric synthesis method for preparation of solifenacin and specifically, discloses a preparation method of solifenacin. The method comprises that ortho-substituted aldehyde as a raw material undergoes a reaction under catalysis of rhodium and a chiral sulfoxide-olefin ligand to produce a key intermediate for high enantioselective addition, and the intermediate is further functionalized and cyclized to form solifenacin. The method is easy to operate, needs mild reaction conditions and has high efficiency and high selectivity.
A PROCESS FOR THE PREPARATION OF SOLIFENACIN SALTS AND THEIR INCLUSION INTO PHARMACEUTICAL DOSAGE FORMS
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Page/Page column 32-33, (2010/04/03)
The invention relates to the synthesis of solifenacin, the preparation of its salts and their inclusion into pharmaceutically acceptable dosage forms.
