1245614-59-8Relevant articles and documents
Solvent-free synthesis of pyrimidine nucleoside-aminophosphonate hybrids and their biological activity evaluation
Zhang, Xinying,Qu, Yingying,Fan, Xuesen,Bores,Feng, Dong,Andrei, Graciela,Snoeck, Robert,De Clercq, Erik,Loiseau, Philippe M.
, p. 616 - 627 (2010)
A novel and highly efficient one-pot three-component synthesis of α-aminophosphonates under neat condition was developed. By employing this method, hybrid compounds of aminophosphonate with pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2′- deoxyuridine, aniline and dimethyl phosphite. The antiviral and antileishmanial activities of these novel hybrid compounds were also studied but none were found to be active.